Evidence map›Paper›PMID 34477463›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Hydrogen sulfide-dependent microvascular vasodilation is improved following chronic sulfhydryl-donating antihypertensive pharmacotherapy in adults with hypertension.

Gabrielle A Dillon, Anna E Stanhewicz, Corinna Serviente, Jody L Greaney, Lacy M Alexander

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Comparing cutaneous NO-dependent vasodilation between young males and females.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease.International journal of molecular sciences · 2023
    Review
  7. New developments in translational microcirculatory research.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  8. Article
  9. Article
  10. Assessments of microvascular function in organ systems.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gabrielle A DillonNoll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.ORCID 0000-0001-5365-2852
Anna E StanhewiczNoll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Corinna ServienteNoll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Jody L GreaneyNoll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Lacy M AlexanderNoll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania.
Pennsylvania State University · USUniversity of Iowa · US

Funding

Essential Hypertension & Human Skin Blood FlowR01HL093238 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI ALEXANDER, LACY M. · 2009 to 2018
$4.3M
Psychosocial Determinants and Biological Pathway to Healthy Aging (Pathways)T32AG049676 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI LYNN M. MARTIRE · 2016 to 2026
$3.9M
Peripheral and Central Mechanisms of Neurovascular Dysfunction in Human DepressionR00HL133414 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI GREANEY, JODY · 2019 to 2021
$746k
Daily stress processes and sympathetic reactivity in depressionR21MH123928 · NIMH · UNIVERSITY OF TEXAS ARLINGTON · PI GREANEY, JODY · 2021 to 2022
$521k
HHS | National Institutes of Health (NIH) NIH HL093238HHS | National Institutes of Health (NIH) NIH T-32-5T32AG049676NHLBI NIH HHS R00 HL133414NHLBI NIH HHS R01 HL093238NIA NIH HHS T32 AG049676NIMH NIH HHS R21 MH123928
6 · The paper itself

Abstract

Hypertension is characterized by systemic microvascular endothelial dysfunction, in part due to a functional absence of hydrogen sulfide (H

Indexed as

AgedAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsBlood PressureCaptoprilFemaleHumansHydrogen SulfideHypertensionMaleMicrocirculationMiddle AgedNitric OxideProof of Concept StudyProspective StudiesSkinAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsCaptoprilHydrogen SulfideNitric Oxideblood pressureendothelium-dependent dilationhydrogen sulfideintradermal microdialysisnitric oxide-dependent dilation

Identifiers

PMID34477463
PMCPMC8803310
OpenAlexW3198403876

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.