Evidence map›Paper›PMID 34487237›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2021

Large-scale phenotyping of ABR P1-N1 amplitudes before and after exposure to noise in 69 strains of mice.

Joel Lavinsky, Aline Mendonça, Mariele Bressan, Vagner Antonio Rodrigues da Silva, Guilherme Kasperbauer, Juemei Wang, Pezhman Salehi, Ely Cheikh Boussaty, Rick Adam Friedman

Abstract read
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In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Joel LavinskyFederal University of Rio Grande do Sul, Sarmento Leite Street, 500, Porto Alegre, 90035-190, Brazil. joel.lavinsky@ufrgs.br.ORCID http://orcid.org/0000-0002-0377-5704
Aline MendonçaFederal University of Rio Grande do Sul, Sarmento Leite Street, 500, Porto Alegre, 90035-190, Brazil.
Mariele BressanFederal University of Rio Grande do Sul, Sarmento Leite Street, 500, Porto Alegre, 90035-190, Brazil.
Vagner Antonio Rodrigues da SilvaDepartamento de Otorrinolaringologia, Faculdade de Ciências Médicas (FCM), Universidade Estadual de Campinas (Unicamp), Cirurgia de Cabeça e Pescoço, Campinas, SP, Brazil.
Guilherme KasperbauerFederal University of Rio Grande do Sul, Sarmento Leite Street, 500, Porto Alegre, 90035-190, Brazil.
Juemei WangUniversity of Southern California, 1501 San Pablo St, Los Angeles, CA, 90033, USA.
Pezhman SalehiNortheast Ohio Medical University, 4209 OH-44, Rootstown, OH, 44272, USA.
Ely Cheikh BoussatyDivision of Otolaryngology, Department of Surgery, University of California, San Diego, 9500 Gilman Drive, Mail Code 0666, La Jolla, CA, 92093, USA.
Rick Adam FriedmanUniversity of California, San Diego, 9444 Medical Center Drive, Mail Code 0768, La Jolla, CA, 92037, USA.
Universidade Federal do Rio Grande do Sul · BRUniversity of California San Diego · USNortheast Ohio Medical University · USUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Southern California · US

Funding

High-Resolution Mapping of Susceptibility Genes for NIHLR01DC010856 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FRIEDMAN, RICK A · 2011 to 2015
$2.2M
NIDCD NIH HHS R01 DC010856
6 · The paper itself

Abstract

ABR wave I amplitude represents the synapse of auditory nerve fibers with the inner hair cell and is highly correlated with synapse counts. Cochlear synaptopathy, the loss of synaptic connections between inner hair cells and auditory nerve fibers, has been well-demonstrated in animal models of noise-induced hearing loss. The peak-to-peak wave I amplitude was determined at baseline and 2 weeks after noise exposure. We determined the ABR wave I amplitude at 80 dB SPL at the frequencies of 8, 12, 16, 24, and 32 kHz. A total of 69 strains (1-8 mice/strain) were analyzed. A statistically significant post-noise reduction in wave I amplitude was observed in all the tested frequencies (p < 0.00001). We identify distinct patterns of noise susceptibility and make this complete phenotypic dataset available for general use. This data establishes a new resource for the study of NIHL in mice and we hope this database will be a useful tool to expand the research in this field.

Indexed as

Evoked Potentials, Auditory, Brain StemHearing Loss, Noise-InducedAnimalsAuditory ThresholdCochleaMiceNoise

Identifiers

PMID34487237
OpenAlexW3198782631

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.