Evidence map›Paper›PMID 34489868›Full record

ArticleFrontiers in endocrinology2021

First-in-Human Evaluation of Positron Emission Tomography/Computed Tomography With [

Hiroyuki Fujimoto, Naotaka Fujita, Keita Hamamatsu, Takaaki Murakami, Yuji Nakamoto, Tsuneo Saga, Takayoshi Ishimori, Yoichi Shimizu, Hiroyuki Watanabe, Kohei Sano and 11 more

Open access · goldAbstract readClinical Trial, Phase I
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. [Endocrine journal · 2026
    Review
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  12. New Long-Acting [Journal of medicinal chemistry · 2023
    Article
  13. Review
  14. Noninvasive quantitative evaluation of viable islet grafts usingFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  15. Review
  16. Frontiers in endocrinology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Hiroyuki FujimotoRadioisotope Research Center, Agency of Health, Safety and Environment, Kyoto University, Kyoto, Japan.
Naotaka FujitaDepartment of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Keita HamamatsuDepartment of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takaaki MurakamiDepartment of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yuji NakamotoDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tsuneo SagaDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takayoshi IshimoriDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yoichi ShimizuDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hiroyuki WatanabeDepartment of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Kohei SanoDepartment of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Norio HaradaDepartment of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hiroshi NakamuraResearch and Development Division, Arkray, Inc., Kyoto, Japan.
Kentaro ToyodaDepartment of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hiroyuki KimuraDepartment of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Shunsaku NakagawaDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan.
Mitsuharu HiraiResearch and Development Division, Arkray, Inc., Kyoto, Japan.
Atsushi MurakamiResearch and Development Division, Arkray, Inc., Kyoto, Japan.
Masahiro OnoDepartment of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Kaori TogashiDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hideo SajiDepartment of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Nobuya InagakiDepartment of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kyoto University · JPArkray (Japan) · JPKyoto University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic β-cell mass (BCM) has a central importance in the pathophysiology of diabetes mellitus. Recently, pancreatic β-cell-specific imaging, especially positron emission tomography (PET) with exendin-based probes, has emerged for non-invasive evaluation of BCM. We developed a novel exendin-based probe labeled with fluorine-18, [

Indexed as

AdultBlood GlucoseExenatideFluorine RadioisotopesGlucagon-Like Peptide-1 ReceptorHealthy VolunteersHumansMalePancreasPositron Emission Tomography Computed TomographyRadiopharmaceuticalsTissue DistributionYoung AdultBlood GlucoseExenatideFluorine-18Fluorine RadioisotopesGlucagon-Like Peptide-1 ReceptorRadiopharmaceuticalsexendin-4first-in-human studyglucagon-like peptide-1 receptor (GLP-1R)PETβ-cell imaging

Identifiers

PMID34489868
PMCPMC8417326
OpenAlexW3195645034

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.