Evidence mapPaperPMID 34489869Full record

ArticleFrontiers in endocrinology2021

Simulation-Based Evaluation of Treatment Adjustment to Exercise in Type 1 Diabetes.

Julia Deichmann, Sara Bachmann, Marie-Anne Burckhardt, Gabor Szinnai, Hans-Michael Kaltenbach

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Julia DeichmannDepartment of Biosystems Science and Engineering and Swiss Institute of Bioinformatics (SIB), ETH Zurich, Basel, Switzerland.
Sara BachmannPediatric Endocrinology and Diabetology, University Children's Hospital Basel, and Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Marie-Anne BurckhardtPediatric Endocrinology and Diabetology, University Children's Hospital Basel, and Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Gabor SzinnaiPediatric Endocrinology and Diabetology, University Children's Hospital Basel, and Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Hans-Michael KaltenbachDepartment of Biosystems Science and Engineering and Swiss Institute of Bioinformatics (SIB), ETH Zurich, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regular exercise is beneficial and recommended for people with type 1 diabetes, but increased glucose demand and changes in insulin sensitivity require treatment adjustments to prevent exercise-induced hypoglycemia. Several different adjustment strategies based on insulin bolus reductions and additional carbohydrate intake have been proposed, but large inter- and intraindividual variability and studies using different exercise duration, intensity, and timing impede a direct comparison of their effects. In this study, we use a mathematical model of the glucoregulatory system and implement published guidelines and strategies

Indexed as

Computer SimulationDrug Dosage CalculationsBlood GlucoseDiabetes Mellitus, Type 1Dietary CarbohydratesExerciseGuideline AdherenceHumansHypoglycemiaHypoglycemic AgentsInsulinInsulin ResistanceMealsModels, TheoreticalPrecision MedicineBlood GlucoseDietary CarbohydratesHypoglycemic AgentsInsulinexercisehypoglycemiainsulin sensitivitymodelingphysical activitytreatment adjustmenttype 1 diabetes

Identifiers

PMID34489869
PMCPMC8417413

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.