Evidence map›Paper›PMID 34490283›Full record

ArticleFrontiers in medicine2021

Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19.

Leandro Jimenez, Ana Campos Codo, Vanderson de Souza Sampaio, Antonio E R Oliveira, Lucas Kaoru Kobo Ferreira, Gustavo Gastão Davanzo, Lauar de Brito Monteiro, João Victor Virgilio-da-Silva, Mayla Gabriela Silva Borba, Gabriela Fabiano de Souza and 11 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  3. Association of COVID-19 Severity with Comorbidities: Results from the World Trade Center Health Registry.International journal of environmental research and public health · 2025
    Article
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  6. The Functions of SARS-CoV-2 Receptors in Diabetes-Related Severe COVID-19.International journal of molecular sciences · 2024
    Review
  7. Article
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  18. HJournal of anesthesia · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 1 country.

Leandro JimenezDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Ana Campos CodoDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Vanderson de Souza SampaioFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Antonio E R OliveiraDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Lucas Kaoru Kobo FerreiraDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Gustavo Gastão DavanzoDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Lauar de Brito MonteiroDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
João Victor Virgilio-da-SilvaDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Mayla Gabriela Silva BorbaFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Gabriela Fabiano de SouzaDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Nathalia ZiniFaculdade de Medicina de São José do Rio Preto, São Paulo, Brazil.
Flora de Andrade GandolfiFaculdade de Medicina de São José do Rio Preto, São Paulo, Brazil.
Stéfanie Primon MuraroDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
José Luiz Proença-ModenaDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Fernando Almeida ValFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Gisely Cardoso MeloFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Wuelton Marcelo MonteiroFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Maurício Lacerda NogueiraFaculdade de Medicina de São José do Rio Preto, São Paulo, Brazil.
Marcus Vinícius Guimarães LacerdaFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Pedro M Moraes-VieiraDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Helder I NakayaDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRFaculdade de Medicina de São José do Rio Preto · BRUniversidade de São Paulo · BRUniversidade Federal do Amazonas · BRUniversidade do Estado do Amazonas · BRFundação de Medicina Tropical · BRHospital Israelita Albert Einstein · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect a broad range of human tissues by using the host receptor angiotensin-converting enzyme 2 (ACE2). Individuals with comorbidities associated with severe COVID-19 display higher levels of

Indexed as

Barrett's esophagusCOVID-19pHproton pump inhibitorsSARS-CoV-2

Identifiers

PMID34490283
PMCPMC8417536
OpenAlexW3195015299

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.