Evidence map›Paper›PMID 34491424›Full record

SynthesisAmino acids2021

The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review.

Mishti Khatri, Robert J Naughton, Tom Clifford, Liam D Harper, Liam Corr

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.

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  17. The Impact of Ageing on Fibrillar Collagens.Sub-cellular biochemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mishti KhatriSchool of Human and Health Sciences, University of Huddersfield, Huddersfield, UK.
Robert J NaughtonSchool of Human and Health Sciences, University of Huddersfield, Huddersfield, UK.ORCID http://orcid.org/0000-0002-9878-0396
Tom CliffordSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.ORCID http://orcid.org/0000-0003-0484-2953
Liam D HarperSchool of Human and Health Sciences, University of Huddersfield, Huddersfield, UK. L.Harper@hud.ac.uk.ORCID http://orcid.org/0000-0002-2089-4799
Liam CorrSchool of Human and Health Sciences, University of Huddersfield, Huddersfield, UK.ORCID http://orcid.org/0000-0001-7439-1372
University of Huddersfield · GBLoughborough University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collagen peptide supplementation (COL), in conjunction with exercise, may be beneficial for the management of degenerative bone and joint disorders. This is likely due to stimulatory effects of COL and exercise on the extracellular matrix of connective tissues, improving structure and load-bearing capabilities. This systematic review aims to evaluate the current literature available on the combined impact of COL and exercise. Following Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, a literature search of three electronic databases-PubMed, Web of Science and CINAHL-was conducted in June 2020. Fifteen randomised controlled trials were selected after screening 856 articles. The study populations included 12 studies in recreational athletes, 2 studies in elderly participants and 1 in untrained pre-menopausal women. Study outcomes were categorised into four topics: (i) joint pain and recovery from joint injuries, (ii) body composition, (iii) muscle soreness and recovery from exercise, and (iv) muscle protein synthesis (MPS) and collagen synthesis. The results indicated that COL is most beneficial in improving joint functionality and reducing joint pain. Certain improvements in body composition, strength and muscle recovery were present. Collagen synthesis rates were elevated with 15 g/day COL but did not have a significant impact on MPS when compared to isonitrogenous higher quality protein sources. Exact mechanisms for these adaptations are unclear, with future research using larger sample sizes, elite athletes, female participants and more precise outcome measures such as muscle biopsies and magnetic imagery.

Indexed as

ExerciseBody CompositionCollagenDietary SupplementsHumansJointsMuscle, SkeletalMyalgiaPeptidesCollagenPeptidesFat free massGelatinJoint healthJoint painMuscle damageProtein

Identifiers

PMID34491424
PMCPMC8521576
OpenAlexW3197861238

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.