Evidence map›Paper›PMID 34492282›Full record

ArticleExperimental eye research2021

In vivo imaging of the inner retinal layer structure in mice after eye-opening using visible-light optical coherence tomography.

Lisa Beckmann, Zhen Cai, James Cole, David A Miller, Mingna Liu, Marta Grannonico, Xian Zhang, Hyun Jung Ryu, Peter A Netland, Xiaorong Liu and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Localization of Ceramide Synthase 5 in Mouse Retina.The Journal of comparative neurology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Lisa BeckmannDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Zhen CaiDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
James ColeDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
David A MillerDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Mingna LiuDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Marta GrannonicoDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Xian ZhangDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Hyun Jung RyuDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Peter A NetlandDepartment of Ophthalmology, University of Virginia, Charlottesville, VA, USA.
Xiaorong LiuDepartment of Biology, University of Virginia, Charlottesville, VA, USA; Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA; Department of Psychology, University of Virginia, Charlottesville, VA, USA. Electronic address: xl8n@virginia.edu.
Hao F ZhangDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA. Electronic address: hfzhang@northwestern.edu.
Northwestern University · USUniversity of Virginia · US

Funding

ER Stress and Diabetic RetinopathyR01EY019949 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZHANG, SARAH X · 2010 to 2023
$5.5M
Visual Signal Transformation in the Retinocollicular PathwayR01EY026286 · NEI · UNIVERSITY OF VIRGINIA · PI Jianhua Cang · 2016 to 2026
$4.4M
Investigating oxygen metabolism in diabetic retinopathyR01EY026078 · NEI · NORTHWESTERN UNIVERSITY · PI SHEIBANI, NADER, ZHANG, HAO F · 2016 to 2020
$2.3M
Investigating nanoscale neuronal damages in early glaucoma towards clinical optical detectionR01EY029121 · NEI · NORTHWESTERN UNIVERSITY · PI LIU, XIAORONG, ZHANG, HAO F · 2018 to 2021
$2.0M
Mechanisms underlying the formation of the cornea and ocular surface epitheliumR01EY028304 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KUME, TSUTOMU · 2018 to 2021
$1.6M
NEI NIH HHS R01 EY019949NEI NIH HHS R01 EY026078NEI NIH HHS R01 EY026286NEI NIH HHS R01 EY028304NEI NIH HHS R01 EY029121
6 · The paper itself

Abstract

The growth of the mouse eye and retina after birth is a dynamic, highly regulated process. In this study, we applied visible-light optical coherence tomography (vis-OCT), a non-invasive imaging technique, to examine developing retinal layer structures after eye-opening. We introduced a resampled circumpapillary B-scan averaging technique to improve the inter-layer contrast, enabling retinal layer thickness measurements as early as postnatal day 13 (P13) - right after eye-opening. We confirmed vis-OCT measurements using ex vivo confocal microscopy of retinal sections at different ages. Our results demonstrate that vis-OCT can visualize the developmental murine retinal layer structure in vivo, which offers us new opportunities to better characterize the pathological alterations in mouse models of developmental eye diseases.

Indexed as

AnimalsAnimals, NewbornLightMiceMice, Inbred C57BLMicroscopy, ConfocalRetinaTomography, Optical CoherenceIn vivo imagingOptical coherence tomographyRetinal development

Identifiers

PMID34492282
PMCPMC10061273
OpenAlexW3197061401

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.