Trial reportClinics (Sao Paulo, Brazil)2021
Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apnea.
Trial report in Clinics (Sao Paulo, Brazil), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 4 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Evaluation of the effectiveness of exercise therapy for irritable bowel syndrome: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Comparative effects of weight-loss diet, exercise training, respiratory muscle training, and oropharyngeal muscle training in obstructive sleep apnea: a systematic review and network meta-analysis.Frontiers in medicine · 2026Pooled it
- Effects of six different exercise therapies on sleep indices, cardiopulmonary endurance, and body composition in patients with sleep-related breathing disorders: network meta-analysis of 40 RCTs.Frontiers in physiology · 2026Pooled it
- Exercise training improves blood pressure reactivity to stress: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Article
- A Fully Replicable Exercise Program for Individuals with Sleep-Disordered Breathing: Protocol Design and Training Load Monitoring.Journal of functional morphology and kinesiology · 2025Article
- Effects of exercise and a lifestyle app on sleep disordered breathing, physical health and quality of life.ERJ open research · 2025Article
- Knowledge, attitudes, and practices of physicians regarding multidisciplinary treatment of obstructive sleep apnea: a cross-sectional study.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effects of exercise training (ET) on muscle sympathetic nerve activity (MSNA) and executive performance during Stroop Color Word Test (SCWT) also referred to as mental stress test.
methodsForty-four individuals with obstructive sleep apnea (OSA) and no significant co-morbidities were randomized into 2 groups; 15 individuals completed the control period, and 18 individuals completed the ET. Mini-mental state of examination and intelligence quotient were also assessed. MSNA assessed by microneurography, heart rate by electrocardiography, blood pressure (automated oscillometric device) were measured at baseline and during 3 min of the SCWT. Peak oxygen uptake (VO2 peak) was evaluated using cardiopulmonary exercise testing. Executive performance was assessed by the total correct responses during 3 min of the SCWT. ET consisted of 3 weekly sessions of aerobic exercise, resistance exercises, and flexibility (72 sessions, achieved in 40±3.9 weeks).
resultsBaseline parameters were similar between groups. Heart rate, blood pressure, and MSNA responses during SCWT were similar between groups (p>0.05). The comparisons between groups showed that the changes in VO2 (4.7±0.8 vs -1.2±0.4) and apnea-hypopnea index (-7.4±3.1 vs 5.5±3.3) in the exercise-trained group were significantly greater than those observed in the control group respectively (p<0.05) after intervention. ET reduced MSNA responses (p<0.05) and significantly increased the number of correct answers (12.4%) during SCWT. The number of correct answers was unchanged in the control group (p>0.05).
conclusionsET improves sympathetic response and executive performance during SCWT, suggesting a prominent positive impact of ET on prefrontal functioning in individuals with OSA. ClinicalTrials.gov: NCT002289625.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.