ArticleFrontiers in immunology2021
Single-Cell Analysis of the Neonatal Immune System Across the Gestational Age Continuum.
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Impact of Extreme Prematurity, Chorioamnionitis, and Sepsis on Neonatal Monocyte Characteristics and Functions.Journal of innate immunity · 2024Trial
- Immune pathways and prenatal/perinatal environmental exposures contribute to epigenetic gestational age prediction and acceleration.Epigenetics · 2026Article
- Perturbation of the preterm human immune system in early life.JCI insight · 2026Article
- The Pathophysiology of Spontaneous Preterm Birth: Emerging Mechanisms Reviewed by the Preterm Birth International Collaborative.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- The immune system of preterm infants: an overview.Frontiers in immunology · 2026Review
- Triglyceride profiles in preterm infants reveal dynamic and age-specific trajectories.Frontiers in pediatrics · 2026Article
- Immunopathological signatures in congenital tuberculosis-a case-matched study.Frontiers in immunology · 2026Article
- Perturbation of the Preterm Human Immune System in Early Life.medRxiv : the preprint server for health sciences · 2025Article
- Conditional similarity triplets enable covariate-informed representations of single-cell data.BMC bioinformatics · 2025Article
- Evolution of the umbilical cord blood proteome across gestational development.Scientific reports · 2025Article
- DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life.Nature communications · 2024Observational
- Conditional Similarity Triplets Enable Covariate-Informed Representations of Single-Cell Data.Research square · 2024Article
- Evolution of the Umbilical Cord Blood Proteome Across Gestational Development.medRxiv : the preprint server for health sciences · 2024Article
- scLKME: A Landmark-based Approach for Generating Multi-cellular Sample Embeddings from Single-cell Data.bioRxiv : the preprint server for biology · 2023Article
- Comparative Analysis of the Pre-Parturition and Post-Parturition Genital Tract Microbiota in Plateau Bangor Sewa Sheep.Veterinary sciences · 2023Article
- Increased Expression of Anaphylatoxin C5a-Receptor-1 in Neutrophils and Natural Killer Cells of Preterm Infants.International journal of molecular sciences · 2023Article
- Prevention of Chronic Morbidities in Extremely Premature Newborns with LISA-nCPAP Respiratory Therapy and Adjuvant Perinatal Strategies.Antioxidants (Basel, Switzerland) · 2023Review
- Olfactomedin-4-Positive Neutrophils in Neonates: Link to Systemic Inflammation and Bronchopulmonary Dysplasia.Neonatology · 2023Article
- Omics approaches: interactions at the maternal-fetal interface and origins of child health and disease.Pediatric research · 2023Review
- Differential dynamics of bone graft transplantation and mesenchymal stem cell therapy during bone defect healing in a murine critical size defect.Journal of orthopaedic translation · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 1 institution in 1 country.
Funding
Abstract
Although most causes of death and morbidity in premature infants are related to immune maladaptation, the premature immune system remains poorly understood. We provide a comprehensive single-cell depiction of the neonatal immune system at birth across the spectrum of viable gestational age (GA), ranging from 25 weeks to term. A mass cytometry immunoassay interrogated all major immune cell subsets, including signaling activity and responsiveness to stimulation. An elastic net model described the relationship between GA and immunome (R=0.85, p=8.75e-14), and unsupervised clustering highlighted previously unrecognized GA-dependent immune dynamics, including decreasing basal MAP-kinase/NFκB signaling in antigen presenting cells; increasing responsiveness of cytotoxic lymphocytes to interferon-α; and decreasing frequency of regulatory and invariant T cells, including NKT-like cells and CD8
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.