Evidence map›Paper›PMID 34497682›Full record

ArticleOxidative medicine and cellular longevity2021

Novel Role of miR-18a-5p and Galanin in Rat Lung Ischemia Reperfusion-Mediated Response.

Kun Xiao, Lei Song, Ye Hu, Wanxue He, Fei Hou, Peng Yan, Jianqiao Xu, Kaifei Wang, Yi Tao, Dan Li and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kun XiaoCenter of Pulmonary & Critical Care Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-8039-3283
Lei SongDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130061, China.ORCID https://orcid.org/0000-0002-4115-065X
Ye HuCenter of Pulmonary & Critical Care Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-6863-6596
Wanxue HeMedical School of Chinese People's Liberation Army (PLA), Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-9561-9927
Fei HouMedical School of Chinese People's Liberation Army (PLA), Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0000-0003-1928-072X
Peng YanCenter of Pulmonary & Critical Care Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-2398-6189
Jianqiao XuCenter of Pulmonary & Critical Care Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-8608-8052
Kaifei WangCenter of Pulmonary & Critical Care Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-2698-5755
Yi TaoMedical School of Chinese People's Liberation Army (PLA), Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-7244-0086
Dan LiDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130061, China.ORCID https://orcid.org/0000-0002-3036-2374
Lixin XieCenter of Pulmonary & Critical Care Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-1091-2041
Chinese PLA General Hospital · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung ischemia reperfusion (IR) is known to occur after lung transplantation or cardiac bypass. IR leads to tissue inflammation and damage and is also associated with increased morbidity and mortality. Various receptors are known to partake in activation of the innate immune system, but the downstream mechanism of tissue damage and inflammation is yet unknown. MicroRNAs (miRNAs) are in the forefront in regulating ischemia reperfusion injury and are involved in inflammatory response. Here, we have identified by high-throughput approach and evaluated a distinct set of miRNAs that may play a role in response to IR in rat lung tissue. The top three differentially expressed miRNAs were validated through quantitative PCRs in the IR rat lung model and an

Indexed as

AnimalsGalaninMicroRNAsProtein PrecursorsRatsRats, Sprague-DawleyReperfusion InjuryGalaninGal protein, ratMicroRNAsProtein Precursors

Identifiers

PMID34497682
PMCPMC8420977
OpenAlexW3193509954

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.