Evidence map›Paper›PMID 34498445›Full record

ArticleHaematologica2022

Stored blood has compromised oxygen unloading kinetics that can be normalized with rejuvenation and predicted from corpuscular side-scatter.

Killian Donovan, Athinoula Meli, Francesca Cendali, Kyung Chan Park, Rebecca Cardigan, Simon Stanworth, Stuart McKechnie, Angelo D'Alessandro, Peter A Smethurst, Pawel Swietach

Abstract read
In one paragraph

Article in Haematologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Trial
  2. Article
  3. High-Throughput Metabolomics in Transfusion Medicine.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. It's in your blood: The impact of age, sex, genetic factors and exposures on stored red blood cell metabolism.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Killian DonovanDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, Oxford.
Athinoula MeliComponent Development Laboratory, NHS Blood and Transplant, Cambridge.
Francesca CendaliDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Kyung Chan ParkDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, Oxford.
Rebecca CardiganComponent Development Laboratory, NHS Blood and Transplant, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, Cambridge.
Simon StanworthTransfusion Medicine, NHS Blood and Transplant, Oxford, England; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, England; Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme.
Stuart McKechnieAdult Intensive Care Unit, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Peter A SmethurstComponent Development Laboratory, NHS Blood and Transplant, Cambridge.
Pawel SwietachDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, Oxford. pawel.swietach@dpag.ox.ac.uk.

Funding

Resuscitation Strategies for Achieving Thrombo-inflammatory HomeostasisRM1GM131968 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI COHEN, MITCHELL, D'ALESSANDRO, ANGELO · 2019 to 2023
$11.3M
The Impact of Oxidative Stress on Erythocyte BiologyR01HL148151 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ALESSANDRO, ANGELO, KARAFIN, MATTHEW S · 2019 to 2022
$8.9M
The role of ferroptosis in red cell aging in vivo and in vitroR01HL146442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Angelo D'Alessandro, Adam N. Goldfarb · 2019 to 2026
$5.4M
Interactions between the ADORA2b/Sphk1axis and the AE1-Hb switch in red blood cell aging in vivo and in vitroR01HL149714 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2023
$2.6M
MIRAGES: Metabolic Investigation of Red blood cells as a function of Aging, Genetics, Environment, and StorageR21HL150032 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2021
$414k
British Heart Foundation RG/15/9/31534NHLBI NIH HHS R01 HL146442NHLBI NIH HHS R01 HL148151NHLBI NIH HHS R01 HL149714NHLBI NIH HHS R21 HL150032NIGMS NIH HHS RM1 GM131968
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

OxygenRejuvenationBlood PreservationErythrocytesHumansKineticsOxygen

Identifiers

PMID34498445
PMCPMC8719080

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.