Evidence map›Paper›PMID 34498676›Full record

ArticleEuropean heart journal. Cardiovascular pharmacotherapy2021

Advances in the understanding of excitation-contraction coupling: the pulsing quest for drugs against heart failure and arrhythmias.

Urna Kansakar, Fahimeh Varzideh, Stanislovas S Jankauskas, Jessica Gambardella, Bruno Trimarco, Gaetano Santulli

Abstract readLetter
In one paragraph

Article in European heart journal. Cardiovascular pharmacotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Ongoing and Future Clinical Trials of Pharmacotherapy for Heart Failure.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024
    Review
  6. Review
  7. Article
  8. In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic MoleculeThe Journal of pharmacology and experimental therapeutics · 2023
    Article
  9. Article
  10. Review
  11. Review
  12. Glycation of ryanodine receptor in circulating lymphocytes predicts the response to cardiac resynchronization therapy.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022
    Article
  13. Article
  14. Article
  15. Heart failure in diabetes.Metabolism: clinical and experimental · 2021
    Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Urna KansakarDepartments of Medicine (Cardiology) and Molecular Pharmacology, Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Einstein-Sinai Diabetes Research Center (ES-DRC), Fleisher Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, 1300 Morris PARK AVENUE, New York City, 10461, NY, USA.
Fahimeh VarzidehDepartments of Medicine (Cardiology) and Molecular Pharmacology, Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Einstein-Sinai Diabetes Research Center (ES-DRC), Fleisher Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, 1300 Morris PARK AVENUE, New York City, 10461, NY, USA.
Stanislovas S JankauskasDepartments of Medicine (Cardiology) and Molecular Pharmacology, Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Einstein-Sinai Diabetes Research Center (ES-DRC), Fleisher Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, 1300 Morris PARK AVENUE, New York City, 10461, NY, USA.
Jessica GambardellaDepartments of Medicine (Cardiology) and Molecular Pharmacology, Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Einstein-Sinai Diabetes Research Center (ES-DRC), Fleisher Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, 1300 Morris PARK AVENUE, New York City, 10461, NY, USA.
Bruno TrimarcoInternational Translational Research and Medical Education (ITME) Consortium and Department of Advanced Biomedical Sciences, "Federico II" University, Via Sergio Pansini, 5, 80131, Naples, Italy.
Gaetano SantulliDepartments of Medicine (Cardiology) and Molecular Pharmacology, Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Einstein-Sinai Diabetes Research Center (ES-DRC), Fleisher Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, 1300 Morris PARK AVENUE, New York City, 10461, NY, USA.ORCID 0000-0001-7231-375X

Funding

Functional role of IP3 receptors in the regulation of cardiac myofibroblastsR01HL146691 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SANTULLI, GAETANO · 2019 to 2023
$2.1M
Beta Cell Intracellular Calcium and DiabetesR01DK123259 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SANTULLI, GAETANO · 2020 to 2023
$1.7M
NHLBI NIH HHS R01 HL146691NIDDK NIH HHS R01 DK123259
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Excitation Contraction CouplingHeart FailureArrhythmias, CardiacHeart RateHumans

Identifiers

PMID34498676
PMCPMC9034200

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.