Evidence map›Paper›PMID 34502107›Full record

ReviewInternational journal of molecular sciences2021

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration.

Steffen Emmert, Sven Pantermehl, Aenne Foth, Janine Waletzko-Hellwig, Georg Hellwig, Rainer Bader, Sabine Illner, Niels Grabow, Sander Bekeschus, Klaus-Dieter Weltmann and 2 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Article
  6. Review
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  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Steffen EmmertClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, Germany.
Sven PantermehlClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, Germany.
Aenne FothClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, Germany.
Janine Waletzko-HellwigDepartment of Oral, Maxillofacial and Plastic Surgery, University Medical Center Rostock, 18057 Rostock, Germany.
Georg HellwigClinic and Policlinic for Orthopedics, University Medical Center Rostock, 18057 Rostock, Germany.
Rainer BaderClinic and Policlinic for Orthopedics, University Medical Center Rostock, 18057 Rostock, Germany.
Sabine IllnerInstitute for Biomedical Engineering, University Medical Center Rostock, 18119 Rostock, Germany.
Niels GrabowInstitute for Biomedical Engineering, University Medical Center Rostock, 18119 Rostock, Germany.
Sander BekeschusZIK Plasmatis, Leibniz Institute for Plasma Science and Technology (INP), 17489 Greifswald, Germany.ORCID 0000-0002-8773-8862
Klaus-Dieter WeltmannZIK Plasmatis, Leibniz Institute for Plasma Science and Technology (INP), 17489 Greifswald, Germany.
Ole JungClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, Germany.
Lars BoeckmannClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, Germany.ORCID 0000-0003-0098-6546

Funding

Bundesministerium für Bildung und Forschung 03COV06ABundesministerium für Bildung und Forschung 03Z22D511Bundesministerium für Bildung und Forschung 03Z22Di1Bundesministerium für Bildung und Forschung 03Z22DN11Bundesministerium für Bildung und Forschung 16GW0344KDamp Stiftung 2017-05Deutsche Forschungsgemeinschaft EM 68/13-1European Social Fund ESF/14-BM-A55-0001/18European Social Fund ESF/14-BM-A55-0006/18European Social Fund ESF/14-BM-A55-0012/18Ferdinand-Eisenberger StiftungStiftung Tumorforschung Kopf-HalsTBI, Ministry of Commerce, Occupation, and Health of Mecklenburg-Vorpommern TBI-V-1-349-VBW-120VDI, Ministry of Education and Research, Germany 16GW0345
6 · The paper itself

Abstract

Skin regeneration is a quite complex process. Epidermal differentiation alone takes about 30 days and is highly regulated. Wounds, especially chronic wounds, affect 2% to 3% of the elderly population and comprise a heterogeneous group of diseases. The prevailing reasons to develop skin wounds include venous and/or arterial circulatory disorders, diabetes, or constant pressure to the skin (decubitus). The hallmarks of modern wound treatment include debridement of dead tissue, disinfection, wound dressings that keep the wound moist but still allow air exchange, and compression bandages. Despite all these efforts there is still a huge treatment resistance and wounds will not heal. This calls for new and more efficient treatment options in combination with novel biocompatible skin scaffolds. Cold atmospheric pressure plasma (CAP) is such an innovative addition to the treatment armamentarium. In one CAP application, antimicrobial effects, wound acidification, enhanced microcirculations and cell stimulation can be achieved. It is evident that CAP treatment, in combination with novel bioengineered, biocompatible and biodegradable electrospun scaffolds, has the potential of fostering wound healing by promoting remodeling and epithelialization along such temporarily applied skin replacement scaffolds.

Indexed as

Wound HealingAnimalsHumansNanofibersPlasma GasesPressure UlcerTissue ScaffoldsPlasma Gasesasymmetric membranesblood flow enhancementdisinfectionelectrospinningnatural and synthetic nanofibersplasma medicineskin regenerationwound healing

Identifiers

PMID34502107
PMCPMC8430875

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.