Evidence map›Paper›PMID 34502226›Full record

ArticleInternational journal of molecular sciences2021

NOP53 Suppresses Autophagy through

Young-Eun Cho, Yong-Jun Kim, Sun Lee, Jae-Hoon Park

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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  4. Review
  5. Article
  6. Review
  7. Association ofFrontiers in genetics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Young-Eun ChoDepartment of Pathology, College of Medicine, Kyung Hee University, Seoul 02453, Korea.
Yong-Jun KimDepartment of Pathology, College of Medicine, Kyung Hee University, Seoul 02453, Korea.ORCID 0000-0002-5374-712X
Sun LeeDepartment of Pathology, College of Medicine, Kyung Hee University, Seoul 02453, Korea.
Jae-Hoon ParkDepartment of Pathology, College of Medicine, Kyung Hee University, Seoul 02453, Korea.

Funding

National Research Foundation of Korea 013R1A2A2A01009006National Research Foundation of Korea 2011-0030072National Research Foundation of Korea 2016R1D1A1A09918014
6 · The paper itself

Abstract

Autophagy is an evolutionally conserved process that recycles aged or damaged intracellular components through a lysosome-dependent pathway. Although this multistep process is propagated in the cytoplasm by the orchestrated activity of the mTOR complex, phosphatidylinositol 3-kinase, and a set of autophagy-related proteins (ATGs), recent investigations have suggested that autophagy is tightly regulated by nuclear events. Thus, it is conceivable that the nucleolus, as a stress-sensing and -responding intranuclear organelle, plays a role in autophagy regulation, but much is unknown concerning the nucleolar controls in autophagy. In this report, we show a novel nucleolar-cytoplasmic axis that regulates the cytoplasmic autophagy process: nucleolar protein NOP53 regulates the autophagic flux through two divergent pathways, the

Indexed as

AutophagyCell NucleolusCell NucleusHEK293 CellsHistonesHumansMicrotubule-Associated ProteinsPhosphorylationTranscription FactorsTumor Suppressor ProteinsHistonesMAP1LC3B protein, humanMicrotubule-Associated ProteinsNOP53 protein, humanTranscription FactorsTumor Suppressor ProteinsZKSCAN3 protein, humanautophagyLC3BNOP53nucleolusZKSCAN3

Identifiers

PMID34502226
PMCPMC8430719

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.