Evidence map›Paper›PMID 34502313›Full record

ArticleInternational journal of molecular sciences2021

A Mutation in DNA Polymerase α Rescues

Thomas Eekhout, José Antonio Pedroza-Garcia, Pooneh Kalhorzadeh, Geert De Jaeger, Lieven De Veylder

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Thomas EekhoutDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent, Belgium.ORCID 0000-0002-2878-1553
José Antonio Pedroza-GarciaDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent, Belgium.ORCID 0000-0001-8258-0157
Pooneh KalhorzadehDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent, Belgium.
Geert De JaegerDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent, Belgium.
Lieven De VeylderDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent, Belgium.
Ghent University · BE

Funding

Research Foundation Flanders G011420N and G010820N
6 · The paper itself

Abstract

During DNA replication, the WEE1 kinase is responsible for safeguarding genomic integrity by phosphorylating and thus inhibiting cyclin-dependent kinases (CDKs), which are the driving force of the cell cycle. Consequentially,

Indexed as

MutationAntisickling AgentsArabidopsisArabidopsis ProteinsCell CycleDNA DamageDNA Polymerase IDrug ResistanceHydroxyureaPhosphorylationProtein Serine-Threonine KinasesAntisickling AgentsArabidopsis ProteinsDNA Polymerase IHydroxyureaProtein Serine-Threonine KinasesWEE1 protein, Arabidopsiscell cycle checkpointDNA damagereplication stress

Identifiers

PMID34502313
PMCPMC8430855
OpenAlexW3198240693

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.