ArticleJournal of obesity & metabolic syndrome2021
Association between Variations in Body Mass Index and Cognitive Function in Older Korean Adults.
Article in Journal of obesity & metabolic syndrome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Body weight and BMI variability linked to dementia risk: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- Visit-to-visit body mass index variability in relation to longitudinal cognitive changes in Chinese adults: a retrospective cohort study.BMC public health · 2025Article
- Association of Vegetable and Fruit Consumption Patterns with Cognitive Function in Older People with Different BMI Ranges: Findings from China.Clinical interventions in aging · 2025Article
- Body mass index and trajectories of the cognition among Chinese middle and old-aged adults.BMC geriatrics · 2022Article
- Body Weight Variability: A Marker for Increased Risk or a Causative Factor for Dementia?Journal of obesity & metabolic syndrome · 2021Article
- Effect of Controlling the Cardiovascular Risk Factors on the Cognitive Decline Prevention in the Elderly: A Systematic Review.Basic and clinical neuroscienceReview
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough several studies have assessed obesity and cognitive impairment, most of these studies focus on body mass index (BMI) and cognitive impairment. Therefore to better understand the importance of weight maintenance with aging, this study investigated the relationship between variations in weight and cognitive impairment using the Korean version of the Mini-Mental State Examination (K-MMSE) in individuals aged 45 years or older in Korea.
methodsData on 3,477 adults with normal cognitive function (K-MMSE ≥24) at baseline were acquired from the Korean Longitudinal Study of Aging (KLoSA) 2006-2016. The association between weight variability and risk of cognitive impairment was assessed using multiple logistic regression models. We also assessed weight variability and change in cognitive function over the 6-year follow-up using multiple linear regression.
resultsOverall, higher variations in BMI were associated with cognitive impairment. Patients in the quintile with the highest variation (Q5) in BMI (mean of BMI changes, 2.69) showed the greatest degree of cognitive impairments (adjusted odds ratio, 1.52; 95% confidence interval [CI], 1.08-2.14; P for trend=0.016). Furthermore, a higher frequency in the number of times (3 times) the patient's body weight changed was associated with a lower cognitive function (adjusted odds ratio, 3.42; 95% CI, 1.67-7.03;
conclusionIn this nationally representative study, weight variability was associated with a higher risk of cognitive decline during mid- and late-life stages.
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