Evidence map›Paper›PMID 34504113›Full record

ArticleScientific reports2021

Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter.

Janani S Iyer, Biwei Yin, Konstantina M Stankovic, Guillermo J Tearney

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Intracochlear Imaging Using IVUS and OFDI: A Cadaveric Feasibility Study.Laryngoscope investigative otolaryngology · 2025
    Article
  5. The State of High-Resolution Imaging of the Human Inner Ear: A Look Into the Black Box.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Review
  7. Imaging theJournal of biomedical optics · 2025
    Article
  8. Article
  9. Expression ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Janani S Iyer *Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, 243 Charles St, Boston, MA, 02114, USA.
Biwei Yin *Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Konstantina M StankovicDepartment of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, 243 Charles St, Boston, MA, 02114, USA. kstankovic@stanford.edu.
Guillermo J TearneyWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA. GTEARNEY@PARTNERS.ORG.
Massachusetts General Hospital · USHarvard University · USMassachusetts Eye and Ear Infirmary · US

Funding

Natural History of Vulnerable Coronary PlaquesR01HL076398 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BOUMA, BRETT E, TEARNEY, GUILLERMO J · 2004 to 2015
$7.5M
NHLBI NIH HHS R01 HL076398
6 · The paper itself

Abstract

Sensorineural hearing loss (SNHL) is one of the most profound public health concerns of the modern era, affecting 466 million people today, and projected to affect 900 million by the year 2050. Advances in both diagnostics and therapeutics for SNHL have been impeded by the human cochlea's inaccessibility for in vivo imaging, resulting from its extremely small size, convoluted coiled configuration, fragility, and deep encasement in dense bone. Here, we develop and demonstrate the ability of a sub-millimeter-diameter, flexible endoscopic probe interfaced with a micro-optical coherence tomography (μOCT) imaging system to enable micron-scale imaging of the inner ear's sensory epithelium in cadaveric human inner ears.

Indexed as

CathetersAnimalsCadaverCochleaDisease Models, AnimalHearing Loss, SensorineuralHumansMiceMice, Inbred CBANoiseTomography, Optical Coherence

Identifiers

PMID34504113
PMCPMC8429662
OpenAlexW3198352739

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.