Evidence map›Paper›PMID 34505352›Full record

SynthesisESC heart failure2021

Heart failure and atrial flutter: a systematic review of current knowledge and practices.

Michael J Diamant, Jason G Andrade, Sean A Virani, Pardeep S Jhund, Mark C Petrie, Nathaniel M Hawkins

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Michael J DiamantDivision of Cardiology, Royal Columbian Hospital, New Westminster, British Columbia, Canada.ORCID 0000-0002-3907-1557
Jason G AndradeDivision of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
Sean A ViraniDivision of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
Pardeep S JhundBHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Mark C PetrieBHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Nathaniel M HawkinsDivision of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
University of British Columbia · CAUniversity of Glasgow · GBRoyal Columbian Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the interplay between heart failure (HF) and atrial fibrillation (AF) has been extensively studied, little is known regarding HF and atrial flutter (AFL), which may be managed differently. We reviewed the incidence, prevalence, and predictors of HF in AFL and vice versa, and the outcomes of treatment of AFL in HF. A systematic literature review of PubMed/Medline and EMBASE yielded 65 studies for inclusion and qualitative synthesis. No study described the incidence or prevalence of AFL in unselected patients with HF. Most cohorts enrolled patients with AF/AFL as interchangeable diagnoses, or highly selected patients with tachycardia-induced cardiomyopathy. The prevalence of HF in AFL ranged from 6% to 56%. However, the phenotype of HF was never defined by left ventricular ejection fraction (LVEF). No studies reported the predictors, phenotype, and prognostic implications of AFL in HF. There was significant variation in treatments studied, including the proportion that underwent ablation. When systolic dysfunction was tachycardia-mediated, catheter ablation demonstrated LVEF normalization in up to 88%, as well as reduced cardiovascular mortality. In summary, AFL and HF often coexist but are understudied, with no randomized trial data to inform care. Further research is warranted to define the epidemiology and establish optimal management.

Indexed as

Atrial FlutterCatheter AblationHeart FailureHumansStroke VolumeVentricular Function, LeftArrhythmiaAtrial flutterCatheter ablationHeart failureLeft ventricular systolic dysfunctionSystematic review

Identifiers

PMID34505352
PMCPMC8712920
OpenAlexW3196357234

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.