Evidence map›Paper›PMID 34511013›Full record

ArticleAnnals of medicine2021

Some characteristics of hyperglycaemic crisis differ between patients with and without COVID-19 at a safety-net hospital in a cross-sectional study.

Arnav Shah, Andrew Deak, Shaneisha Allen, Elayna Silfani, Christina Koppin, Yaara Zisman-Ilani, Imali Sirisena, Christina Rose, Daniel Rubin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arnav ShahLewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Andrew DeakLewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Shaneisha AllenSection of Endocrinology, Diabetes, and Metabolism, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Elayna SilfaniSchool of Pharmacy, Temple University, Philadelphia, PA, USA.
Christina KoppinLewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Yaara Zisman-IlaniDepartment of Social and Behavioral Sciences, College of Public Health, Temple University, Philadelphia, PA, USA.
Imali SirisenaSection of Endocrinology, Diabetes, and Metabolism, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Christina RoseSchool of Pharmacy, Temple University, Philadelphia, PA, USA.
Daniel RubinSection of Endocrinology, Diabetes, and Metabolism, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare patients with DKA, hyperglycaemic hyperosmolar syndrome (HHS), or mixed DKA-HHS and COVID-19 [COVID (+)] to COVID-19-negative (-) [COVID (-)] patients with DKA/HHS from a low-income, racially/ethnically diverse catchment area.

methodsA cross-sectional study was conducted with patients admitted to an urban academic medical center between 1 March and 30 July 2020. Eligible patients met lab criteria for either DKA or HHS. Mixed DKA-HHS was defined as meeting all criteria for either DKA or HHS with at least 1 criterion for the other diagnosis.

resultsA total of 82 participants were stratified by COVID-19 status and type of hyperglycaemic crisis [26 COVID (+) and 56 COVID (-)]. A majority were either Black or Hispanic. Compared with COVID (-) patients, COVID (+) patients were older, more Hispanic and more likely to have type 2 diabetes (T2D, 73% vs 48%, DISCUSSION: Compared with COVID (-) patients, COVID (+) patients with DKA/HHS are more likely to have T2D. Despite less severe metabolic acidosis, COVID (+) patients may require more time to resolve the hyperglycaemic crisis and experience more hypoglycaemia while suffering greater LOS and risk of mortality. Larger studies are needed to examine whether differences in management between COVID (+) and (-) patients affect outcomes with DKA/HHS.

Indexed as

Acid-Base EquilibriumAdultAgedAge FactorsComorbidityCOVID-19Cross-Sectional StudiesDiabetes Mellitus, Type 2Diabetic KetoacidosisFemaleFluid TherapyGlucocorticoidsHumansHydrogen-Ion ConcentrationHyperglycemic Hyperosmolar Nonketotic ComaLength of StayGlucocorticoidsCOVID-19diabetic ketoacidosishyperglycaemic emergencieshyperglycaemic hyperosmolar syndrome

Identifiers

PMID34511013
PMCPMC8439248

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.