Evidence map›Paper›PMID 34511166›Full record

Trial reportZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2021

A prospective randomized controlled study on mouse nerve growth factor in the treatment of global developmental delay in children.

Jin-Jing Yuan, De Wu, Wen-Wen Wang, Jun Duan, Xiao-Yan Xu, Jiu-Lai Tang

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. [Clinical characteristics of six cases of neurofibromatosis type 1-associated infantile epileptic spasms syndrome].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jin-Jing YuanDepartment of Pediatric Neurology Rehabilitation Center, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
De WuDepartment of Pediatric Neurology Rehabilitation Center, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Wen-Wen WangDepartment of Pediatric Neurology Rehabilitation Center, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Jun DuanDepartment of Pediatric Neurology Rehabilitation Center, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Xiao-Yan XuDepartment of Pediatric Neurology Rehabilitation Center, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Jiu-Lai TangDepartment of Pediatric Neurology Rehabilitation Center, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo study the clinical effect of mouse nerve growth factor (mNGF) in the treatment of children with global developmental delay (GDD).

methodsA prospective clinical trial was conducted in 60 children with GDD who were treated in the First Affiliated Hospital of Anhui Medical University between July 2016 and July 2017. These children were randomly divided into two groups: conventional rehabilitation treatment and mNGF treatment group (

resultsBefore treatment and after 1.5 months of treatment, there was no significant difference in the developmental quotient (DQ) of each functional area of the Gesell Developmental Scale between the mNGF treatment and conventional rehabilitation treatment groups (

conclusionsIn children with GDD, routine rehabilitation training combined with mNGF therapy can significantly improve their cognitive, motor, and social abilities.

Indexed as

Developmental DisabilitiesNerve Growth FactorAnimalsChildHumansMiceProspective StudiesSocial SkillsNerve Growth FactorChildClinical effectGlobal developmental delayMouse nerve growth factor

Identifiers

PMID34511166
PMCPMC8428910
OpenAlexW3201648067

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.