ArticleTherapeutics and clinical risk management2021
Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM.
Article in Therapeutics and clinical risk management, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Linear Inverse Association Between Triglyceride Glucose-Body Mass Index and Osteoporosis in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Evaluation of the severity of lumbar osteoporosis in patients with type 2 diabetes mellitus using q-Dixon magnetic resonance imaging.American journal of translational research · 2026Article
- A Review of the Relationship Between Insulin and Bone Health.Biomedicines · 2025Review
- Role of TyG, TyG-BMI and METS-IR in osteoporosis risk among older men: a retrospective cohort study.Asia Pacific journal of clinical nutrition · 2025Article
- Development and validation of a novel glucolipid metabolism-related nomogram to enhance the predictive performance for osteoporosis complications in prediabetic and diabetic patients.Lipids in health and disease · 2025Article
- Type 2 Diabetes Mellitus and Osteoporosis: Site-Specific Bone Mineral Density Variations and Metabolic Correlations in Postmenopausal Saudi Women.Medicina (Kaunas, Lithuania) · 2025Article
- Dapagliflozin combined with metformin improves blood glucose, bone metabolism and bone mineral density in elderly patients with type 2 diabetes mellitus complicated with osteoporosis.The Kaohsiung journal of medical sciences · 2025Article
- Additional role of low-density lipoprotein cholesterol on the risk of osteoporosis in men with or without coronary heart disease: a real-world longitudinal study.Journal of geriatric cardiology : JGC · 2025Article
- Elevated Uric Acid/Albumin Ratio Predicts Poor Coronary Collateral Circulation in Type 2 Diabetic Patients With Stable Coronary Artery Disease.Journal of diabetes research · 2025Article
- The association between different insulin resistance indexes and bone health in the elderly.PloS one · 2025Article
- Insulin Resistance and Bone Mineral Density: A Comprehensive Examination Using UK Biobank Data.Healthcare (Basel, Switzerland) · 2024Article
- Exploring the Interplay between Vitamin D, Insulin Resistance, Obesity and Skeletal Health.Journal of bone metabolism · 2024Article
- Association between triglyceride glucose index and total bone mineral density: a cross-sectional study from NHANES 2011-2018.Scientific reports · 2024Article
- The impact of diabetes, anemia, and renal function in the relationship between osteoporosis and fasting blood glucose among Taiwanese women: a cross-sectional study.BMC women's health · 2024Article
- The METS-IR is independently related to bone mineral density, FRAX score, and bone fracture among U.S. non-diabetic adults: a cross-sectional study based on NHANES.BMC musculoskeletal disorders · 2023Article
- The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis.Biomedicines · 2023Review
- The metabolic score of insulin resistance is positively correlated with bone mineral density in postmenopausal patients with type 2 diabetes mellitus.Scientific reports · 2023Article
- Triglyceride Glucose Index is Strongly Associated with a Fragility Fracture in Postmenopausal Elderly Females with Type 2 Diabetes Mellitus Combined with Osteoporosis: A 6-Year Follow-Up Study.Clinical interventions in aging · 2023Article
- Oral Administration of Isovitexin, a Naturally Occurring Apigenin Derivative Showed Osteoanabolic Effect in Ovariectomized Mice: A Comparative Study with Teriparatide.Calcified tissue international · 2022Article
- Application of urine C-peptide creatinine ratio in type 2 diabetic patients with different levels of renal function.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo explore the relationship between insulin resistance and osteoporosis risk in Chinese patients with type 2 diabetes mellitus (T2DM).
methodsA total of 234 T2DM patients were retrospectively analyzed, and their lumbar bone mineral density (BMD) and insulin resistance using C-peptide-based homeostasis model of insulin resistance [HOMA-IR (CP)] were assessed. Univariate and multivariable logistic regression methods were used to evaluate the association between HOMA-IR (CP) and osteoporosis, and subgroup analysis was performed on female and male patients.
resultsAfter fully adjusting the covariates, the association between HOMA-IR (CP) and osteoporosis was only significant in female patients (P = 0.022); the interaction effect with gender was significant (P for interaction <0.05). Curve fitting showed that the relationship between HOMA-IR (CP) and osteoporosis in women was nonlinear. When HOMA-IR (CP) is <4.00, its effect on osteoporosis was not significant (P = 0.474); when HOMA-IR (CP) is >4.00, the risk of osteoporosis increased significantly, with OR = 26.88 (95% CI: 2.75-262.69, P = 0.005). The relationship between insulin resistance and osteoporosis risk in T2DM patients is significantly affected by gender.
conclusionThe higher the degree of insulin resistance in female patients, the greater the risk of osteoporosis, but the two are not linearly associated.
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