Evidence map›Paper›PMID 34512625›Full record

ArticleFrontiers in immunology2021

Identification of Genes Encoding Antimicrobial Proteins in Langerhans Cells.

Aislyn Oulee, Feiyang Ma, Rosane M B Teles, Bruno J de Andrade Silva, Matteo Pellegrini, Eynav Klechevsky, Andrew N Harman, Jake W Rhodes, Robert L Modlin

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Aislyn OuleeDivision of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Feiyang MaDivision of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Rosane M B TelesDivision of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Bruno J de Andrade SilvaDivision of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Matteo PellegriniDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Eynav KlechevskyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Andrew N HarmanCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia.
Jake W RhodesCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia.
Robert L ModlinDivision of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · USUniversity of Sydney · AUWashington University in St. Louis · US

Funding

Molecular Analysis of the Host Immune Response in LeprosyR01AI022553 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROBERT L MODLIN · 1989 to 2026
$15.7M
TCR GAMMA/DELTA LYMPHOCYTES IN HUMAN SKIN LESIONSR01AR040312 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MODLIN, ROBERT L · 1990 to 2025
$10.4M
Microbiology and Metagenomics CoreP50AR080594 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBERT L MODLIN · 2022 to 2026
$9.2M
The skin microbiome in acneR01AR074302 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GALLO, RICHARD L, MODLIN, ROBERT L · 2018 to 2022
$2.6M
IL-26 in host defense against infection by intracellular bacteria in skinR01AR073252 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2019 to 2023
$2.1M
The Role of CD5 in Tumor ImmunityR01CA245277 · NCI · WASHINGTON UNIVERSITY · PI KLECHEVSKY, EYNAV YAFIT · 2020 to 2024
$1.8M
Harnessing Human Dendritic Cell Subsets in Skin for the Design of Novel ImmunotherapiesR01AR075959 · NIAMS · WASHINGTON UNIVERSITY · PI KLECHEVSKY, EYNAV YAFIT · 2019 to 2023
$1.7M
MECHANICALLY-OPTIMIZED SYNTHETIC DENDRITIC CELLS FOR THE EXPANSION OF ANTIGEN-SPECIFIC T CELLSR21EB024767 · NIBIB · WASHINGTON UNIVERSITY · PI KLECHEVSKY, EYNAV YAFIT, PATHAK, AMIT · 2018 to 2020
$610k
NCI NIH HHS R01 CA245277NIAID NIH HHS R01 AI022553NIAMS NIH HHS P50 AR080594NIAMS NIH HHS R01 AR040312NIAMS NIH HHS R01 AR073252NIAMS NIH HHS R01 AR074302NIAMS NIH HHS R01 AR075959NIBIB NIH HHS R21 EB024767
6 · The paper itself

Abstract

Langerhans cells (LCs) reside in the epidermis where they are poised to mount an antimicrobial response against microbial pathogens invading from the outside environment. To elucidate potential pathways by which LCs contribute to host defense, we mined published LC transcriptomes deposited in GEO and the scientific literature for genes that participate in antimicrobial responses. Overall, we identified 31 genes in LCs that encode proteins that contribute to antimicrobial activity, ten of which were cross-validated in at least two separate experiments. Seven of these ten antimicrobial genes encode chemokines,

Indexed as

TranscriptomeAntimicrobial PeptidesCells, CulturedDatabases, GeneticEpidermisGene Expression ProfilingHost-Pathogen InteractionsHumansLangerhans CellsStaphylococcal Skin InfectionsStaphylococcus aureusAntimicrobial Peptidesantimicrobial peptidesbioinformaticsdendritic cellsimmunityLangerhans cellsskintranscriptome

Identifiers

PMID34512625
PMCPMC8426439
OpenAlexW3195134200

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.