ReviewFrontiers in genetics2021
The Evolution of the Hallmarks of Aging.
Review in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 71 citations in OpenAlex.
- Evolutionary genetics of ageing.Nature reviews. Genetics · 2026Review
- Histological aging signatures for monitoring tissue-specific aging and disease.Nature medicine · 2026Article
- Frequency-Stratified Changes in BDNF, IGF-1, and Cognitive Screening Scores Following a 16-Week Hatha Yoga Program in Older Women: A Quasi-Experimental Study.Healthcare (Basel, Switzerland) · 2026Article
- A 15-Year Computational Twin Modeling Study of Botulinum Toxin A Frequency and Age-Related Facial Aging.Aesthetic plastic surgery · 2026Article
- Review
- Article
- Mitochondria as a Therapeutic Target in Neurodegeneration: Strategies for Restoring Cellular Homeostasis.Current neuropharmacology · 2026Review
- Gerobiotics: Exploring the Potential and Limitations of Repurposing Probiotics in Addressing Aging Hallmarks and Chronic Diseases.Probiotics and antimicrobial proteins · 2026Review
- Parallel Selection for Longevity in Mammals and Birds.bioRxiv : the preprint server for biology · 2025Article
- Telomerase Depletion Accelerates Ageing of the Zebrafish Brain.Aging cell · 2025Article
- Germ cells and the aging niche: a systems approach to reproductive longevity.Journal of assisted reproduction and genetics · 2025Review
- Protective Effect of Carvacrol against Oxidative Damage in Aged Rats.Central nervous system agents in medicinal chemistry · 2025Article
- Agelessness is possible under the disposable soma theory but system complexity makes it unlikely.Journal of theoretical biology · 2024Article
- Article
- Deciphering the aging process through single-cell cytometric technologies.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2024Review
- An Introductory Guide to Using Bloomington Drosophila Stock Center and FlyBase for Aging Research.Cells · 2024Review
- Open Genes-a new comprehensive database of human genes associated with aging and longevity.Nucleic acids research · 2024Article
- Ageing as a two-phase process: theoretical framework.Frontiers in aging · 2024Article
- Smurfness-based two-phase model of ageing helps deconvolve the ageing transcriptional signature.Aging cell · 2023Article
- Informing the Cannabis Conjecture: From Life's Beginnings to Mitochondria, Membranes and the Electrome-A Review.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolutionary theory of aging has set the foundations for a comprehensive understanding of aging. The biology of aging has listed and described the "hallmarks of aging," i.e., cellular and molecular mechanisms involved in human aging. The present paper is the first to infer the order of appearance of the hallmarks of bilaterian and thereby human aging throughout evolution from their presence in progressively narrower clades. Its first result is that all organisms, even non-senescent, have to deal with at least one mechanism of aging - the progressive accumulation of misfolded or unstable proteins. Due to their cumulation, these mechanisms are called "layers of aging." A difference should be made between the first four layers of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.