Evidence map›Paper›PMID 34513987›Full record

ArticleBioMed research international2021

MicroRNA-137 Inhibited Hypoxia-Induced Proliferation of Pulmonary Artery Smooth Muscle Cells by Targeting Calpain-2.

Xiao-Yue Ge, Tian-Tian Zhu, Mao-Zhong Yao, Hong Liu, Qian Wu, Jie Qiao, Wei-Fang Zhang, Chang-Ping Hu

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. The Role of Glutamine and Glutaminase in Pulmonary Hypertension.Frontiers in cardiovascular medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xiao-Yue GeDepartment of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078 Hunan, China.
Tian-Tian ZhuTeaching and Research Office of Clinical Pharmacology, College of Pharmacy, Xinxiang Medical University, Xinxiang, 453003 Henan, China.
Mao-Zhong YaoDepartment of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078 Hunan, China.
Hong LiuDepartment of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078 Hunan, China.
Qian WuDepartment of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078 Hunan, China.
Jie QiaoDepartment of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078 Hunan, China.
Wei-Fang ZhangDepartment of Pharmacy, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006 Jiangxi, China.ORCID https://orcid.org/0000-0002-8421-1395
Chang-Ping HuDepartment of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078 Hunan, China.ORCID https://orcid.org/0000-0001-7375-3415
Central South University · CNNanchang University · CNXinxiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The proliferation of pulmonary artery smooth muscle cells (PASMCs) is an important cause of pulmonary vascular remodeling in pulmonary hypertension (PH). It has been reported that miR-137 inhibits the proliferation of tumor cells. However, whether miR-137 is involved in PH remains unclear. In this study, male Sprague-Dawley rats were subjected to 10% O

Indexed as

AnimalsCalpainCell HypoxiaCell MovementCell ProliferationCells, CulturedHypertension, PulmonaryHypoxiaMaleMicroRNAsMuscle, Smooth, VascularMyocytes, Smooth MusclePulmonary ArteryRatsRats, Sprague-DawleyVascular RemodelingCalpainCapn2 protein, ratMicroRNAsMIRN137 microRNA, rat

Identifiers

PMID34513987
PMCPMC8426064
OpenAlexW3198444924

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.