ArticleBrain communications2021
Neuropathology in the North American sudden unexpected death in epilepsy registry.
Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Forensic neuropathology: 2026 update.Free neuropathology · 2026Review
- Long-term survival after adult epilepsy surgery: Mortality and predictors in a large cohort.Epilepsia · 2025Article
- Sudden unexpected infant death, sudden unexplained death in childhood, and sudden unexpected death in epilepsy.Developmental medicine and child neurology · 2025Review
- Focal granule cell bilamination of the dentate gyrus-its prevalence across the human age spectrum and review of the literature.Journal of neuropathology and experimental neurology · 2025Review
- Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history.Acta neuropathologica · 2024Article
- Review
- Similar brain proteomic signatures in Alzheimer's disease and epilepsy.Acta neuropathologica · 2024Article
- Metabolomic, proteomic, and transcriptomic changes in adults with epilepsy on modified Atkins diet.Epilepsia · 2023Article
- Epilepsy-associated death in the Southwestern Ontario: A clinicopathological correlation study.Brain pathology (Zurich, Switzerland) · 2023Article
- Sudden unexpected death in epilepsy: Investigation of autopsy-based studies.Frontiers in neurology · 2023Article
- Pilot study evaluating everolimus molecular mechanisms in tuberous sclerosis complex and focal cortical dysplasia.PloS one · 2022Article
- Raphe and ventrolateral medulla proteomics in epilepsy and sudden unexpected death in epilepsy.Brain communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Sudden unexpected death in epilepsy is the leading category of epilepsy-related death and the underlying mechanisms are incompletely understood. Risk factors can include a recent history and high frequency of generalized tonic-clonic seizures, which can depress brain activity postictally, impairing respiration, arousal and protective reflexes. Neuropathological findings in sudden unexpected death in epilepsy cases parallel those in other epilepsy patients, with no implication of novel structures or mechanisms in seizure-related deaths. Few large studies have comprehensively reviewed whole brain examination of such patients. We evaluated 92 North American Sudden unexpected death in epilepsy Registry cases with whole brain neuropathological examination by board-certified neuropathologists blinded to the adjudicated cause of death, with an average of 16 brain regions examined per case. The 92 cases included 61 sudden unexpected death in epilepsy (40 definite, 9 definite plus, 6 probable, 6 possible) and 31 people with epilepsy controls who died from other causes. The mean age at death was 34.4 years and 65.2% (60/92) were male. The average age of death was younger for sudden unexpected death in epilepsy cases than for epilepsy controls (30.0 versus 39.6 years;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.