← SGLT2 inhibitors × cardiovascular events

SynthesisJournal of the American Heart Association2021

Sodium-Glucose Cotransporter 2 Inhibitors, All-Cause Mortality, and Cardiovascular Outcomes in Adults with Type 2 Diabetes: A Bayesian Meta-Analysis and Meta-Regression.

Ayodele Odutayo et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 2021

Range includes no effect

No clear effect on deaths

−14%−31% to +5%

Bigger than 4 in 10 for all-cause mortality

As reported

RR 0.86, 95% CI 0.69–1.05 · the paper's word: All-cause mortality

Range includes no effect

No clear effect on deaths

−14%−28% to +1%

Bigger than 4 in 10 for all-cause mortality

As reported

RR 0.86, 95% CI 0.72–1.01 · the paper's word: All-cause mortality

Range includes no effect

No clear effect on cardiovascular events

−22%−39% to +0%

Bigger than 5 in 10 for cardiovascular events

As reported

RR 0.78, 95% CI 0.61–1.00

Range includes no effect

No clear effect on cardiovascular events

−17%−37% to +5%

Bigger than 4 in 10 for cardiovascular events

As reported

RR 0.83, 95% CI 0.63–1.05

+1 more in the walkthrough ↓

Five numbers in the abstract

the abstract, start to end

… [CrI], 0.63-0.97; canagliflozin: RR, 0.86; 95% CrI, 0.69-1.05; dapagliflozin: RR, 0.86; 95% CrI, 0.72-1.01) and cardiovascular mortality (empagliflozin: RR, 0.78; 95% CrI, 0.61-1.00; canagliflozin: RR, 0.83; 95% CrI, 0.63-1.05; dapagliflozin: RR, 0.88; 95% CrI, 0.71-1.08), with a …

← favours treatmentfavours comparator →

could be chance

All-cause mortality

RR 0.860.69–1.05

All-cause mortality

RR 0.860.72–1.01

Cardiovascular events

RR 0.780.61–1.00

Cardiovascular events

RR 0.830.63–1.05

Cardiovascular events

RR 0.880.71–1.08

SGLT2 inhibitorsCardiovascular eventsAll-cause mortality

SGLT2 inhibitors × cardiovascular eventshelps?mixed

unlikelylikely

0.50not counted

SGLT2 inhibitors × all-cause mortalityhelps?mixed

unlikelylikely

0.50not counted

← favours comparatorfavours treatment →

more certainless certain

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18 papers cite it

2021

2022

2023

2024

2025

2026

this paperpooled ittrialcites it

Sodium-Glucose Cotransporter 2 Inhibitors, All-Cause Mortality, and Cardiovascular Outcomes in Adults with Type 2 Diabetes: A Bayesian Meta-Analysis and Meta-Regression.

What the trial testedas reported · 2021

No clear effect on deaths

No clear effect on deaths

No clear effect on cardiovascular events

No clear effect on cardiovascular events

Five numbers in the abstract

Where each one falls

Where it lands on the map

What it changes

Among 18 other studies

18 papers cite it