Evidence map›Paper›PMID 34514871›Full record

ReviewPhysiology (Bethesda, Md.)2022

The Mechanobiology of Vascular Remodeling in the Aging Lung.

Paul B Dieffenbach, Aja Aravamudhan, Laura E Fredenburgh, Daniel J Tschumperlin

Open access · greenAbstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. mBiomolecules · 2026
    Review
  3. Article
  4. Mechanobiology and Resolution of Lung Fibrosis.Annual review of physiology · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Paul B DieffenbachDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Aja AravamudhanDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
Laura E FredenburghDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Daniel J TschumperlinDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.ORCID 0000-0002-5115-9025
Brigham and Women's Hospital · USMayo Clinic · US

Funding

Mechanotransduction and YAP/TAZ Signaling in Pulmonary Arterial HypertensionR01HL137366 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PERRELLA, MARK A, TSCHUMPERLIN, DANIEL J. · 2018 to 2021
$2.7M
YAP/TAZ-mediated Mechanotransduction in Pulmonary Hypertension PathogenesisK08HL143197 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIEFFENBACH, PAUL BRIAN · 2018 to 2021
$679k
American Heart Association-American Stroke Association 17GRNT33660449NHLBI NIH HHS K08 HL143197NHLBI NIH HHS R01 HL137366
6 · The paper itself

Abstract

Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how interacting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.

Indexed as

Vascular DiseasesVascular RemodelingAgingBiophysicsHumansLungmatrixpulmonarysenescencestiffnessvessel

Identifiers

PMID34514871
PMCPMC8742727
OpenAlexW3199150019

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.