ArticleCirculation research2021
PDE1 Inhibition Modulates Ca
Open access · bronzeAbstract read
In one paragraph
Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- International Utah cardiac recovery symposium (U-CARS) 2025:translational and basic science proceedings.Heart failure reviews · 2026Review
- Cyclic nucleotide phosphodiesterases as drug targets.Pharmacological reviews · 2025Review
- Nanodomain cAMP signaling in cardiac pathophysiology: potential for developing targeted therapeutic interventions.Physiological reviews · 2025Review
- Phosphodiesterases: Evolving Concepts and Implications for Human Therapeutics.Annual review of pharmacology and toxicology · 2025Review
- The identification of adenylyl cyclase modulators as potential receptors for 6-nitrodopamine in human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and their relevance in heart inotropism.Frontiers in pharmacology · 2025Article
- SGLT2 inhibitors protect against diabetic cardiomyopathy and atrial fibrillation through a CaMKII independent mechanism.bioRxiv : the preprint server for biology · 2024Article
- Carvedilol Activates a Myofilament Signaling Circuitry to Restore Cardiac Contractility in Heart Failure.JACC. Basic to translational science · 2024Article
- Phosphodiesterase in heart and vessels: from physiology to diseases.Physiological reviews · 2024Review
- Current Targets and Future Directions of Positive Inotropes for Heart Failure.Current medicinal chemistry · 2024Review
- Article
- Cadmium exposure induces a sex-dependent decline in left ventricular cardiac function.Life sciences · 2023Article
- Compartmentalized cAMP signalling and control of cardiac rhythm.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Regulation of cardiac function by cAMP nanodomains.Bioscience reports · 2023Review
- Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Grace K MullerDivision of Cardiology, Department of Medicine (G.K.M., J.S., V.J., Y.W., T.L., W.P.D.J., B.O., M.E.A., D.A.K.), The Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-5433-8571
Joy SongDivision of Cardiology, Department of Medicine (G.K.M., J.S., V.J., Y.W., T.L., W.P.D.J., B.O., M.E.A., D.A.K.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Vivek JaniDivision of Cardiology, Department of Medicine (G.K.M., J.S., V.J., Y.W., T.L., W.P.D.J., B.O., M.E.A., D.A.K.), The Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-3811-4973
Yuejin WuDivision of Cardiology, Department of Medicine (G.K.M., J.S., V.J., Y.W., T.L., W.P.D.J., B.O., M.E.A., D.A.K.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Ting LiuDivision of Cardiology, Department of Medicine (G.K.M., J.S., V.J., Y.W., T.L., W.P.D.J., B.O., M.E.A., D.A.K.), The Johns Hopkins University School of Medicine, Baltimore, MD.
William P D JeffreysDivision of Cardiology, Department of Medicine (G.K.M., J.S., V.J., Y.W., T.L., W.P.D.J., B.O., M.E.A., D.A.K.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Brian O'RourkeDivision of Cardiology, Department of Medicine (G.K.M., J.S., V.J., Y.W., T.L., W.P.D.J., B.O., M.E.A., D.A.K.), The Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-5548-4853
Mark E AndersonDivision of Cardiology, Department of Medicine (G.K.M., J.S., V.J., Y.W., T.L., W.P.D.J., B.O., M.E.A., D.A.K.), The Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0001-6145-5234
David A KassDivision of Cardiology, Department of Medicine (G.K.M., J.S., V.J., Y.W., T.L., W.P.D.J., B.O., M.E.A., D.A.K.), The Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0003-1596-2299
Johns Hopkins University · US
Funding
PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2MMedical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4MLeveraging Protein Kinase G-1 Nanodomain Control and Molecular Targeting to Enhance its Therapeutic Use Against Myocardial DiseaseR35HL135827 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KASS, DAVID ALAN · 2017 to 2023
$6.3MMechanisms of Right Ventricular Dysfunction in Scleroderma-associated PAHR01HL114910 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HASSOUN, PAUL M. · 2012 to 2023
$6.2MCaMKII signaling in physiology, heart failure and arrhythmiasR35HL140034 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ANDERSON, MARK E · 2018 to 2022
$5.2MTargeting Metabo-Redox Network Vulnerability in Heart Failure and Sudden DeathR01HL134821 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FOSTER, D BRIAN, O'ROURKE, BRIAN · 2018 to 2021
$2.1MAmerican Heart Association-American Stroke Association 18POST33960157NHLBI NIH HHS R01 HL114910NHLBI NIH HHS R01 HL134821NHLBI NIH HHS R35 HL135827NHLBI NIH HHS R35 HL140034NHLBI NIH HHS T32 HL007227NIGMS NIH HHS T32 GM136577
Abstract
[Figure: see text].
Indexed as
Myocardial ContractionAnimalsCalcium Channels, L-TypeCells, CulturedCyclic Nucleotide Phosphodiesterases, Type 1Enzyme InhibitorsExcitation Contraction CouplingGuinea PigsHeterocyclic Compounds, 4 or More RingsMaleMyocytes, CardiacCalcium Channels, L-TypeCyclic Nucleotide Phosphodiesterases, Type 1Enzyme InhibitorsHeterocyclic Compounds, 4 or More RingsITI-214L-type calcium channel alpha(1C)excitation contraction couplingmyocardial contractionnucleotidepharmacologyphosphorylation
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.