Evidence map›Paper›PMID 34522133›Full record

ArticleInternational journal of general medicine2021

The Red Blood Cell Distribution Width-Albumin Ratio Was a Potential Prognostic Biomarker for Diabetic Ketoacidosis.

Depu Zhou, Jie Wang, Xiaokun Li

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Article in International journal of general medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

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37citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

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  8. Prognostic value of the red cell distribution width to albumin ratio in predicting mortality in elderly hip fracture patients undergoing hemiarthroplasty.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Observational
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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Depu ZhouDepartment of Endocrinology, Yanbian University Hospital, Yanji, Jilin Province, People's Republic of China.
Jie WangDepartment of Endocrinology, Yanbian University Hospital, Yanji, Jilin Province, People's Republic of China.ORCID 0000-0003-3357-5743
Xiaokun LiDepartment of Endocrinology, Yanbian University Hospital, Yanji, Jilin Province, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe red blood cell distribution width (RDW)-albumin ratio (RA) is a new biomarker, which is d-efined as RDW divided by albumin. This study aimed at determining the prognostic values of RA for diabetic ketoacidosis (DKA).

methodsData were obtained from Medical Information Mart for Intensive Care Database III V1.4 (MIMIC-III) and the RA calculated. Multivariate Cox regression analysis was performed to determine the correlation between RA and 90-day mortality or 365-day mortality. To further investigate the association with RA and mortality, the patients were divided into two groups. The second outcome was the association between the incidence of DKA-related infections and RA.

resultsFor DKA patients in the ICU, RA was significantly correlated with 90-day mortality (HR: 2.1, 95% CI: 1.5, 3.0, p < 0.001) and 365-day mortality (HR: 1.9, 95% CI: 1.5, 2.5, p < 0.001). A high RA was independently correlated with increased 90-day mortality (HR: 7.8, 95% CI: 1.8, 34.0, p for trend <0.001) and 365-day mortality (HR: 5.2, 95% CI: 2.4, 11.3, p for trend <0.001). Moreover, RA was found to be an independent predictor for sepsis and septic shock in patients with DKA (HR: 2.9, 95% CI: 2.0, 4.1, p < 0.001). After adjusting for confounders, the statistical outcome was the same.

conclusionA high RA is significantly correlated with increased all-cause mortality of DKA as well as an increased incidence of DKA-related infections. RA is a potential prognostic marker for DKA.

Indexed as

all-cause mortalitydiabetic ketoacidosisdiabetic ketoacidosis–associated infectionred blood cell distribution width–albumin ratio

Identifiers

PMID34522133
PMCPMC8434876

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.