Evidence map›Paper›PMID 34522608›Full record

ArticlePhotoacoustics2021

Direct measurement of neuronal ensemble activity using photoacoustic imaging in the stimulated Fos-LacZ transgenic rat brain: A proof-of-principle study.

James I Matchynski, Rayyan Manwar, Karl J Kratkiewicz, Rajtarun Madangopal, Veronica A Lennon, Kassem M Makki, Abbey L Reppen, Alexander R Woznicki, Bruce T Hope, Shane A Perrine and 2 more

Open access · goldAbstract read
In one paragraph

Article in Photoacoustics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Couplants in Acoustic Biosensing Systems.Chemosensors (Basel, Switzerland) · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

James I MatchynskiJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.
Rayyan ManwarThe Richard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, USA.
Karl J KratkiewiczDepartment of Biomedical Engineering, Wayne State University, Detroit, MI, USA.
Rajtarun MadangopalThe National Institute on Drug Abuse (NIDA) Intramural Research Program, Baltimore, MD, USA.
Veronica A LennonThe National Institute on Drug Abuse (NIDA) Intramural Research Program, Baltimore, MD, USA.
Kassem M MakkiJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.
Abbey L ReppenJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.
Alexander R WoznickiJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.
Bruce T HopeThe National Institute on Drug Abuse (NIDA) Intramural Research Program, Baltimore, MD, USA.
Shane A PerrineJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.
Alana C ContiJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.
Kamran AvanakiThe Richard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, USA.
Wayne State University · USJohn D. Dingell VA Medical Center · USNational Institute on Drug Abuse · USUniversity of Illinois Chicago · US

Funding

In vivo photoacoustic imaging of prefrontal cortex in rats undergoing fentanyl self-administrationR21DA052657 · NIDA · WAYNE STATE UNIVERSITY · PI AVANAKI, KAMRAN, PERRINE, SHANE ALAN · 2021 to 2022
$415k
Novel method to quantify conditioned fear-based neuronal activity in rat brain in vivo using high-resolution photoacoustic imagingF30MH122093 · NIMH · WAYNE STATE UNIVERSITY · PI MATCHYNSKI, JAMES · 2020 to 2023
$200k
NIDA NIH HHS R21 DA052657NIMH NIH HHS F30 MH122093
6 · The paper itself

Abstract

Measuring neuroactivity underlying complex behaviors facilitates understanding the microcircuitry that supports these behaviors. We have developed a functional and molecular photoacoustic tomography (F/M-PAT) system which allows direct imaging of Fos-expressing neuronal ensembles in Fos-LacZ transgenic rats with a large field-of-view and high spatial resolution. F/M-PAT measures the beta-galactosidase catalyzed enzymatic product of exogenous chromophore X-gal within ensemble neurons. We used an

Indexed as

ANSI, American national standards instituteAP, anterior-posteriorBrainCNR, contrast-to-noise ratioCocaineDMSO, dimethyl sulfoxideDV, dorsal-ventralFear conditioningF/M-PAT, functional molecular photoacoustic tomographyfMRI, functional magnetic resonance imagingFosFOV, field-of-viewGRIN, gradient-indexIL, infralimbic cortexML, medial-lateralmPFC, medial prefrontal cortexNeuronal ensembleOCT, optical coherence tomographyOPO, optical parametric oscillatorPA, photoacousticPBS, phosphate buffer salinePhotoacoustic imagingPL, prelimbic cortexSNR, signal-to-noise ratioUS, ultrasoundX-galX-gal, beta-D-galactosidase

Identifiers

PMID34522608
PMCPMC8426561
OpenAlexW3198842618

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.