Evidence map›Paper›PMID 34522940›Full record

ArticleBiomaterials science2021

Joscha Mulorz, Mahdis Shayan, Caroline Hu, Cynthia Alcazar, Alex H P Chan, Mason Briggs, Yan Wen, Ankita P Walvekar, Anand K Ramasubramanian, Joshua M Spin and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Biomaterials science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Biomedical Applications of Collagen.Bioengineering (Basel, Switzerland) · 2023
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Joscha MulorzVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. ngantina@stanford.edu.
Mahdis ShayanVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. ngantina@stanford.edu.
Caroline HuVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. ngantina@stanford.edu.
Cynthia AlcazarVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. ngantina@stanford.edu.
Alex H P ChanVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. ngantina@stanford.edu.
Mason BriggsStanford University School of Medicine, Department of Obstetrics and Gynecology, Stanford, CA, USA.
Yan WenStanford University School of Medicine, Department of Obstetrics and Gynecology, Stanford, CA, USA.
Ankita P WalvekarDepartment of Chemical and Materials Engineering, San Jose State University, San Jose, CA, USA.
Anand K RamasubramanianDepartment of Chemical and Materials Engineering, San Jose State University, San Jose, CA, USA.
Joshua M SpinVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. ngantina@stanford.edu.ORCID http://orcid.org/0000-0002-4256-9161
Bertha ChenStanford University School of Medicine, Department of Obstetrics and Gynecology, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0783-7319
Philip S TsaoVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. ngantina@stanford.edu.
Ngan F HuangVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. ngantina@stanford.edu.ORCID http://orcid.org/0000-0003-2298-6790
VA Palo Alto Health Care System · USStanford University · USSan Jose State University · US

Funding

Aligned Nanofibrillar Scaffolds Enhance Angiogenesis and Viability in Ischemia: Sex Differences Administrative SupplementR01HL127113 · NHLBI · STANFORD UNIVERSITY · PI HUANG, NGAN F. · 2016 to 2020
$2.5M
Engineered matrix microarrays to enhance the regenerative potential of iPSC-derived endothelial cellsR01HL142718 · NHLBI · STANFORD UNIVERSITY · PI HEILSHORN, SARAH C, HUANG, NGAN F. · 2018 to 2021
$1.6M
Effects of Inhaled Nicotine on Vascular miR-24 Activity and AAA FormationR56HL135654 · NHLBI · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI TSAO, PHILIP S · 2017 to 2017
$300k
Vascularized Cardiac Patch with Physiological Orientation for Myocardial RepairI01BX002310 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI HUANG, NGAN F. · 2015 to 2018
–
Regulatory Role of MicroRNAs in Aging-related Abdominal Aortic Aneurysm DiseaseI01BX002641 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI TSAO, PHILIP S · 2015 to 2019
–
Engineering Vascularized Skeletal Muscle for Treatment of Volumetric Muscle LossI01BX004259 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI Ngan F. Huang · 2019 to 2026
–
American Heart Association-American Stroke Association 0825084FAmerican Heart Association-American Stroke Association 10SDG3040055BLRD VA I01 BX002310BLRD VA I01 BX002641BLRD VA I01 BX004259NHLBI NIH HHS R01 HL127113NHLBI NIH HHS R01 HL142718NHLBI NIH HHS R56 HL135654
6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) is associated with the loss of vascular smooth muscle cells (SMCs) within the vessel wall. Direct delivery of therapeutic cells is challenging due to impaired mechanical integrity of the vessel wall. We hypothesized that porous collagen scaffolds can be an effective vehicle for the delivery of human-derived SMCs to the site of AAA. The purpose was to evaluate if the delivery of cell-seeded scaffolds can abrogate progressive expansion in a mouse model of AAA. Collagen scaffolds seeded with either primary human aortic SMCs or induced pluripotent stem cell derived-smooth muscle progenitor cells (iPSC-SMPs) had >80%

Indexed as

Aortic Aneurysm, AbdominalAdventitiaAnimalsCells, CulturedCollagenMiceMyocytes, Smooth MusclePorositySwineCollagen

Identifiers

PMID34522940
PMCPMC8511090
OpenAlexW3198474333

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.