Evidence map›Paper›PMID 34525342›Full record

ArticleDevelopmental cell2021

A PtdIns(3,4,5)P

Hui Miao, Timothy E Vanderleest, Rashmi Budhathoki, Dinah Loerke, J Todd Blankenship

Open access · greenAbstract read
In one paragraph

Article in Developmental cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hui MiaoDepartment of Biological Sciences, University of Denver, Denver, CO 80208, USA.
Timothy E VanderleestDepartment of Physics, University of Denver, Denver, CO 80208, USA.
Rashmi BudhathokiDepartment of Biological Sciences, University of Denver, Denver, CO 80208, USA.
Dinah LoerkeDepartment of Physics, University of Denver, Denver, CO 80208, USA.
J Todd BlankenshipDepartment of Biological Sciences, University of Denver, Denver, CO 80208, USA. Electronic address: todd.blankenship@du.edu.
University of Denver · US

Funding

Sliding vertex behaviors during epithelial morphogenesis and tissue elongationR01GM127447 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI BLANKENSHIP, JAMES TODD, LOERKE, DINAH · 2018 to 2021
$1.2M
Control of cell ratcheting engagement during epithelial morphogenesisR01GM141243 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI BLANKENSHIP, JAMES TODD, LOERKE, DINAH · 2022 to 2025
$1.2M
Mechanisms of membrane ratcheting during cell intercalationR15GM126422 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI BLANKENSHIP, JAMES TODD · 2017 to 2017
$440k
NIGMS NIH HHS R01 GM127447NIGMS NIH HHS R01 GM141243NIGMS NIH HHS R15 GM126422
6 · The paper itself

Abstract

Force generation in epithelial tissues is often pulsatile, with actomyosin networks generating contractile forces before cyclically disassembling. This pulsed nature of cytoskeletal forces implies that there must be ratcheting mechanisms that drive processive transformations in cell shape. Previous work has shown that force generation is coordinated with endocytic remodeling; however, how ratcheting becomes engaged at specific cell surfaces remains unclear. Here, we report that PtdIns(3,4,5)P

Indexed as

Actin CytoskeletonActomyosinAnimalsCell MembraneCell PolarityCell ShapeCytoskeletonDrosophilaDrosophila ProteinsEpithelial CellsEpitheliumMorphogenesisPhosphatidylinositolsActomyosinDrosophila ProteinsPhosphatidylinositolsapical constrictioncell intercalationcell ratchetingDrosophilagastrulationmembrane traffickingmorphogenesis

Identifiers

PMID34525342
PMCPMC8483019
OpenAlexW3200030537

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.