Evidence map›Paper›PMID 34526895›Full record

ArticleFrontiers in pharmacology2021

Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity Celastrol Mimic with Better Druggability.

Bo Zhou, Yaxia Yuan, Le Shi, Sheng Hu, Dong Wang, Yang Yang, Yuanhu Pan, Dexin Kong, Alexander N Shikov, Pierre Duez and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. A terpenoids database with the chemical content as a novel agronomic trait.Database : the journal of biological databases and curation · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Bo ZhouLaboratory of Natural Medicine and Molecular Engineering, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Yaxia YuanDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Le ShiLaboratory of Natural Medicine and Molecular Engineering, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Sheng HuHubei Cancer Hospital, Wuhan, China.
Dong WangAgricultural Bioinformatics Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan, China.
Yang YangLaboratory of Natural Medicine and Molecular Engineering, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Yuanhu PanNational Reference Laboratory of Veterinary Drug Residues and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, China.
Dexin KongAgricultural Bioinformatics Key Laboratory of Hubei Province, College of Informatics, Huazhong Agricultural University, Wuhan, China.
Alexander N ShikovDepartment of Pharmaceutical Formulations, St. Petersburg State Chemical Pharmaceutical University, St. Petersburg, Russia.
Pierre DuezUnit of Therapeutic Chemistry and Pharmacognosy, University of Mons, Mons, Belgium.
Moonsoo JinDepartment of Radiology, Weill Cornell Medical College, New York, NY, United States.
Xiaohua LiLaboratory of Natural Medicine and Molecular Engineering, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Xuebo HuLaboratory of Natural Medicine and Molecular Engineering, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Huazhong Agricultural University · CNCornell University · USHubei Cancer Hospital · CNSaint - Petersburg State Chemical Pharmaceutical Academy · RUUniversity of Florida · USUniversity of Mons · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is characterized by an excessive body mass, but is also closely associated with metabolic syndrome. And, so far, only limited pharmacological treatments are available for obesity management. Celastrol, a pentacyclic triterpenoid from a traditional Chinese medicine (

Indexed as

celastrolglycyrrhetinic acidGlycyrrhiza uralensisinflammationnatural productsobesityTripterygium wilfordii

Identifiers

PMID34526895
PMCPMC8435713
OpenAlexW3194252643

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.