Evidence map›Paper›PMID 34527428›Full record

ArticleOncoimmunology2021

Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.

Melanie Kienzl, Carina Hasenoehrl, Kathrin Maitz, Arailym Sarsembayeva, Ulrike Taschler, Paulina Valadez-Cosmes, Oliver Kindler, Dusica Ristic, Sofia Raftopoulou, Ana Santiso and 8 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. The biological functions of monoacylglycerol lipase (MAGL) in cancer.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 3 countries.

Melanie KienzlDivision Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.
Carina HasenoehrlDivision Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.
Kathrin MaitzDivision Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.
Arailym SarsembayevaDivision Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.
Ulrike TaschlerInstitute Of Molecular Biosciences, University Of Graz, Graz, Austria.
Paulina Valadez-CosmesDivision Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.
Oliver KindlerDivision Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.
Dusica RisticDivision Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.
Sofia RaftopoulouDivision Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.
Ana SantisoDivision Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.
Thomas BärnthalerDivision Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.
Luka BrcicDiagnostic And Research Institute Of Pathology, Medical University Of Graz, Graz, Austria.
Lisa HahnefeldInstitute Of Clinical Pharmacology, Goethe University, Frankfurt, Germany.
Robert GurkeInstitute Of Clinical Pharmacology, Goethe University, Frankfurt, Germany.
Dominique ThomasInstitute Of Clinical Pharmacology, Goethe University, Frankfurt, Germany.
Gerd GeisslingerInstitute Of Clinical Pharmacology, Goethe University, Frankfurt, Germany.
Julia KarglDivision Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.ORCID 0000-0002-0870-0816
Rudolf SchichoDivision Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.ORCID 0000-0002-5726-4731
Medical University of Graz · ATGoethe University Frankfurt · DEUniversity of Graz · AT

Funding

Austrian Science Fund FWF J 4547Austrian Science Fund FWF P 33325
6 · The paper itself

Abstract

Monoacylglycerol lipase (MGL) expressed in cancer cells influences cancer pathogenesis but the role of MGL in the tumor microenvironment (TME) is less known. Using a syngeneic tumor model with KP cells (Kras

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsAnimalsCD8-Positive T-LymphocytesMiceMonoacylglycerol LipasesMonoglyceridesTumor MicroenvironmentMonoacylglycerol LipasesMonoglycerides2-AGcannabinoid receptorsCD8+ T cellsEndocannabinoidimmune cellslung cancermonoacylglycerol lipase

Identifiers

PMID34527428
PMCPMC8437460
OpenAlexW3201079850

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.