Evidence map›Paper›PMID 34529344›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2022

Maternal serum fructosamine levels and stillbirth: a case-control study of the Stillbirth Collaborative Research Network.

E Arslan, A A Allshouse, J M Page, M W Varner, V Thorsten, C Parker, D J Dudley, G R Saade, R L Goldenberg, B J Stoll and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Fructosamine and HbA1c: A Correlational Study in a Southeast Asian Population.Journal of the ASEAN Federation of Endocrine Societies · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

E ArslanDepartment of Obstetrics and Gynecology, University of Utah Health Sciences, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-9111-0744
A A AllshouseDepartment of Obstetrics and Gynecology, University of Utah Health Sciences, Salt Lake City, Utah, USA.
J M PageDepartment of Obstetrics and Gynecology, University of Utah Health Sciences, Salt Lake City, Utah, USA.
M W VarnerDepartment of Obstetrics and Gynecology, University of Utah Health Sciences, Salt Lake City, Utah, USA.
V ThorstenRTI International, Research Triangle Park, North Carolina, USA.
C ParkerRTI International, Research Triangle Park, North Carolina, USA.
D J DudleyDepartment of Obstetrics and Gynecology, University of Virginia, Charlottesville, Virginia, USA.
G R SaadeDepartment of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
R L GoldenbergDepartment of Obstetrics and Gynecology, Columbia University, New York, New York, USA.
B J StollDepartment of Pediatrics, McGovern Medical School at University of Texas Health Science Center at Houston, Houston, Texas, USA.
C J HogueDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
R BukowskiDepartment of Women's Health, University of Texas Health Science Center at Austin, Austin, Texas, USA.
D ConwayDepartment of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
H PinarDivision of Perinatal Pathology, Brown University School of Medicine, Providence, Rhode Island, USA.
U M ReddyDepartment of Obstetrics and Gynecology, Yale School of Medicine, New Haven, Connecticut, USA.
R M SilverDepartment of Obstetrics and Gynecology, University of Utah Health Sciences, Salt Lake City, Utah, USA.

Funding

Stillbirth NetworkU01HD045954 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI PARKER, CORETTE BREEDEN · 2003 to 2009
$8.4M
University of Utah Center for Clinical and Translational Science-UL1UL1TR000105 · NCATS · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2012 to 2013
$5.1M
Research on the Scope and Causes of Stillbirth in the USU10HD045944 · NICHD · UNIVERSITY OF UTAH · PI SILVER, ROBERT M. · 2003 to 2009
$2.7M
San Antonio Center for the Study of StillbirthU10HD045955 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DUDLEY, DONALD J · 2003 to 2009
$2.4M
Research on the Scope and Causes of Stillbirth in the USU10HD045925 · NICHD · EMORY UNIVERSITY · PI HOGUE, CAROL · 2003 to 2009
$2.3M
RESEARCH ON SCOPE &CAUSES OF STILLBIRTH IN THE USU10HD045953 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI COUSTAN, DONALD R · 2003 to 2009
$2.3M
Scope and Causes of StillbirthU10HD045952 · NICHD · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SAADE, GEORGE R. · 2003 to 2009
$1.9M
Eunice Kennedy Shriver National Institute of Child Health and Human Development U01-HD045954Eunice Kennedy Shriver National Institute of Child Health and Human Development U10-HD045925Eunice Kennedy Shriver National Institute of Child Health and Human Development U10-HD045944Eunice Kennedy Shriver National Institute of Child Health and Human Development U10-HD045952Eunice Kennedy Shriver National Institute of Child Health and Human Development U10-HD045953Eunice Kennedy Shriver National Institute of Child Health and Human Development U10-HD045955NCATS NIH HHS 8UL1TR000105 (formerly UL1RR025764)NCATS NIH HHS UL1 TR000105NICHD NIH HHS U01 HD045954NICHD NIH HHS U10 HD045925NICHD NIH HHS U10 HD045944NICHD NIH HHS U10 HD045952NICHD NIH HHS U10 HD045953NICHD NIH HHS U10 HD045955
6 · The paper itself

Abstract

objectiveTo evaluate the association between maternal fructosamine levels at the time of delivery and stillbirth.

designSecondary analysis of a case-control study.

settingMulticentre study of five geographic catchment areas in the USA. POPULATION: All singleton stillbirths with known diabetes status and fructosamine measurement, and representative live birth controls.

main outcome measuresFructosamine levels in stillbirths and live births among groups were adjusted for potential confounding factors, including diabetes. Optimal thresholds of fructosamine to discriminate stillbirth and live birth.

resultsA total of 529 women with a stillbirth and 1499 women with a live birth were included in the analysis. Mean fructosamine levels were significantly higher in women with a stillbirth than in women with a live birth after adjustment (177 ± 3.05 versus 165 ± 2.89 μmol/L, P < 0.001). The difference in fructosamine levels between stillbirths and live births was greater among women with diabetes (194 ± 8.54 versus 162 ± 3.21 μmol/L), compared with women without diabetes (171 ± 2.50 versus 162 ± 2.56 μmol/L). The area under the curve (AUC) for fructosamine level and stillbirth was 0.634 (0.605-0.663) overall, 0.713 (0.624-0.802) with diabetes and 0.625 (0.595-0.656) with no diabetes.

conclusionsMaternal fructosamine levels at the time of delivery were higher in women with stillbirth compared with women with live birth. Differences were substantial in women with diabetes, suggesting a potential benefit of glycaemic control in women with diabetes during pregnancy. The small differences noted in women without diabetes are not likely to justify routine screening in all cases of stillbirth. TWEETABLE ABSTRACT: Maternal serum fructosamine levels are higher in women with stillbirth than in women with live birth, especially in women with diabetes.

Indexed as

AdultCase-Control StudiesCausalityFemaleFructosamineHumansLive BirthPregnancyRisk FactorsROC CurveStillbirthUnited StatesFructosamineDiabetesfructosaminegestational diabetesstillbirth

Identifiers

PMID34529344
PMCPMC13006978

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.