ReviewFrontiers in medicine2021
Musculoskeletal Changes Across the Lifespan: Nutrition and the Life-Course Approach to Prevention.
Review in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- The Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Co-Transporter-2 Inhibitors on Lean Body Mass in Humans: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Diabetes/metabolism research and reviews · 2026Pooled it
- Effects of Probiotics, Prebiotics, and Synbiotics on Sarcopenia Parameters in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrition reviews · 2025Pooled it
- Pooled it
- Factors associated with handgrip strength across the life course: A systematic review.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- Cosmetic and Application Qualities of the Cream Physiorelax Compared to Another Topical Cream for Musculoskeletal Health Care: An Organoleptic Expert Panel Approach.Journal of cosmetic dermatology · 2025Trial
- Toe Grasp Strength and Its Association with Muscle Mass and Calcaneal Bone Status in Young Adults: A Cross-Sectional Study.Journal of musculoskeletal & neuronal interactions · 2026Article
- Spinal pain and associated factors among young motorcyclists a cross-sectional study with mediating analysis.Scientific reports · 2026Article
- Is Femoral Head Bone Marrow Edema of Unknown Etiology Associated with Acetabular Overcoverage? A CT-Based Three-Dimensional Study.Tomography (Ann Arbor, Mich.) · 2026Article
- Effects of progressive multimodal resistance training with varied muscle actions and range of motion on bone mineral density in osteopenic older women: a pilot study.Frontiers in physiology · 2026Article
- Planetary health diet index and low muscle mass in adults aged 20-60 years: exploratory evaluation of a dairy-upweighted outcome-specific adaptation.Frontiers in nutrition · 2026Article
- Dietary inadequacies and their association with pain severity and disc degeneration in patients surgically treated for degenerative lumbosacral spine disorders.Frontiers in nutrition · 2026Article
- LMS-based continuous reference values for the myokine musclin in serum in children and adults.Frontiers in endocrinology · 2026Article
- REASON CP: a systems-based framework for clinical reasoning to support participation across the lifespan in childhood-onset neurodisability.Frontiers in public health · 2026Review
- Article
- A Cross-Sectional Analysis of Pain, Neck Disability, Functional Performance, and Quality of Life in Patients with Cervical Spondylosis.Journal of clinical medicine · 2025Article
- Gender and Age-Related Decline in Lower Limb Standing Muscle Strength: Benchmarking for Rehabilitation Assessment.Sensors (Basel, Switzerland) · 2025Article
- Towards Sensor-Based Mobility Assessment for Older Adults: A Multimodal Framework Integrating PoseNet Gait Dynamics and InBody Composition.Sensors (Basel, Switzerland) · 2025Article
- Review
- Article
- Effect of Birth Weight on Muscle Strength and Body Composition in Young Adult Men and Women.Cureus · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is characterized by the progressive decline of muscle mass and function, the so-called sarcopenia. Also bone loss is widespread among older people. Sarcopenia and osteopenia/osteoporosis are associated with several adverse outcomes including falls, risk of fractures, functional decline, frailty, and mortality. Recently, the life-course approach to prevent or delay functional decline has become very popular. Regarding musculoskeletal health, there is suggestive evidence that acting during critical or sensitive periods of life in which each person build-up its biological reserves may influence the rate of functional decline in the later stages of life. A life-course approach to musculoskeletal health should take place during early life when plasticity allows more easily the attainment of the peak of the musculoskeletal system driven by environmental stimuli. The rate of the subsequent decline will depend on the peak previously reached. Nutrition and physical exercise are important environmental factors that can influence musculoskeletal development by favoring and maintaining peak bone and muscle mass and strength. Here we provide an overview of body composition changes occurring across the lifespan and strategies based on nutrition and physical exercise to support musculoskeletal health as well as minimizing losses during older life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.