Evidence map›Paper›PMID 34534883›Full record

ArticleJournal of the neurological sciences2021

Biomarkers of kidney function and cognitive ability: A Mendelian randomization study.

Erin L Richard, Linda K McEvoy, Steven Y Cao, Eyal Oren, John E Alcaraz, Andrea Z LaCroix, Rany M Salem

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the neurological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Kidney Function Measures and Mortality: A Mendelian Randomization Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024
    Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Erin L RichardDepartment of Family Medicine and Public Health, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, USA; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, USA. Electronic address: e6richar@ucsd.edu.
Linda K McEvoyHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, USA; Department of Radiology, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, USA.
Steven Y CaoHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, USA.
Eyal OrenGraduate School of Public Health, San Diego State University, 5500 Campanile Dr, San Diego, CA, USA.
John E AlcarazGraduate School of Public Health, San Diego State University, 5500 Campanile Dr, San Diego, CA, USA.
Andrea Z LaCroixHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, USA.
Rany M SalemHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, USA.
University of California, San Diego · USHuman Longevity (United States) · USSan Diego State University · US

Funding

TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3M
UCSD Integrated Cardiovascular Epidemiology FellowshipT32HL079891 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew A Allison · 2007 to 2026
$6.7M
Methods for Genetic Association Analysis of Longitudinal and Multiple PhenotypesR00HL122515 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SALEM, RANY · 2017 to 2019
$732k
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NHLBI NIH HHS R00 HL122515NHLBI NIH HHS T32 HL079891NIGMS NIH HHS P41 GM103504
6 · The paper itself

Abstract

backgroundEstimated glomerular filtration rate (eGFR), albuminuria and serum uric acid (SUA) are markers of kidney function that have been associated with cognitive ability. However, whether these associations are causal is unclear.

methodsWe performed one-sample Mendelian randomization (MR) to estimate the effects of kidney function markers on cognitive performance using data from the UK Biobank. Polygenic scores for SUA, urine albumin to creatinine ratio (ACR), estimated glomerular filtration rate based on serum creatinine (eGFRcre) and serum cystatin C (eGFRcys) were used as instrumental variables, and cognitive function outcomes included tests of verbal-numeric reasoning, reaction time, visual memory, and numeric memory.

resultsWe found no evidence of a causal effect of genetically determined SUA, eGFRcre or eGFRcys on cognitive function outcomes. There was no association between a polygenic score for ACR and verbal-numeric reasoning or numeric memory. However, there was suggestive evidence of a relationship between genetically increased ACR and slower reaction time and worse visual memory. ACR was no longer significantly associated with visual memory in analyses using an unweighted polygenic score and in analyses stratified by sex and age category. Pleiotropy adjusted estimates were directionally consistent with those of the principal analysis but overlapped with the null.

conclusionsThis MR study does not support causal effects of SUA, eGFRcre or eGFRcys on cognitive performance. Genetically increased ACR was associated with slower processing speed and visual memory, but results need confirmation in independent samples.

Indexed as

Mendelian Randomization AnalysisUric AcidBiomarkersCognitionCreatinineGlomerular Filtration RateHumansKidneyBiomarkersCreatinineUric AcidAlbuminuriaCognitionGlomerular filtration rateMendelian randomizationUric acid

Identifiers

PMID34534883
PMCPMC8635776
OpenAlexW3197320615

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.