ArticleHormones and behavior2021
Glucoregulation and coping behavior after chronic stress in rats: Sex differences across the lifespan.
Article in Hormones and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Prefrontal-medullary circuitry is necessary for sex-specific responses to metabolic stress in rats.Endocrinology · 2026Article
- Prefrontal-medullary circuitry is necessary for sex-specific responses to metabolic stress in rats.bioRxiv : the preprint server for biology · 2026Article
- Article
- Sex-specific cardiac remodeling in aged rats after adolescent chronic stress: associations with endocrine and metabolic factors.Biology of sex differences · 2024Article
- Sex-Specific Cardiac Remodeling in Aged Rats after Early-Life Chronic Stress: Associations with Endocrine and Metabolic Factors.bioRxiv : the preprint server for biology · 2024Article
- Cortical-brainstem circuitry attenuates physiological stress reactivity.The Journal of physiology · 2024Article
- Sex-specific prefrontal-hypothalamic control of behavior and stress responding.Psychoneuroendocrinology · 2024Article
- Chronic stress-induced immune dysregulation in breast cancer: Implications of psychosocial factors.Journal of translational internal medicine · 2023Article
- Prefrontal representation of affective stimuli: importance of stress, sex, and context.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Nine-month-long Social Isolation Changes the Levels of Monoamines in the Brain Structures of Rats: A Comparative Study of Neurochemistry and Behavior.Neurochemical research · 2023Article
- Dose mediates the protracted effects of adolescent THC exposure on reward and stress reactivity in males relevant to perturbation of the basolateral amygdala transcriptome.Molecular psychiatry · 2023Article
- Sex differences in autonomic responses to stress: implications for cardiometabolic physiology.American journal of physiology. Endocrinology and metabolism · 2022Review
- Sex- and age-dependent effects of chronic corticosterone exposure on depressive-like, anxiety-like, and fear-related behavior: Role of amygdala glutamate receptors in the rat.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The purpose of the current study was to determine how biological sex shapes behavioral coping and metabolic health across the lifespan after chronic stress. We hypothesized that examining chronic stress-induced behavioral and endocrine outcomes would reveal sex differences in the biological basis of susceptibility. During late adolescence, male and female Sprague-Dawley rats experienced chronic variable stress (CVS). Following completion of CVS, all rats experienced a forced swim test (FST) followed 3 days later by a fasted glucose tolerance test (GTT). The FST was used to determine coping in response to a stressor. Endocrine metabolic function was evaluated in the GTT by measuring glucose and corticosterone, the primary rodent glucocorticoid. Rats then aged to 15 months when the FST and GTT were repeated. In young rats, chronically stressed females exhibited more passive coping and corticosterone release in the FST. Additionally, chronically stressed females had elevated corticosterone and impaired glucose clearance in the GTT. Aging affected all measurements as behavioral and endocrine outcomes were sex specific. Furthermore, regression analysis between hormonal and behavioral responses identified associations depending on sex and stress. Collectively, these data indicate increased female susceptibility to the effects of chronic stress during adolescence. Further, translational investigation of coping style and glucose homeostasis may identify biomarkers for stress-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.