Evidence map›Paper›PMID 34537996›Full record

ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2022

Reciprocal interactions between transforming growth factor beta signaling and collagens: Insights from Caenorhabditis elegans.

Miriam B Goodman, Cathy Savage-Dunn

Abstract read
In one paragraph

Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Miriam B GoodmanDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, California, USA.ORCID 0000-0002-5810-1272
Cathy Savage-DunnDepartment of Biology, Queens College at the City University of New York, New York, New York, USA.ORCID 0000-0002-3457-0509

Funding

Center for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAVID H. HALL, Nathan Schroeder · 2012 to 2026
$9.6M
The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stressR35NS105092 · NINDS · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B · 2018 to 2025
$6.4M
Regulation of Metabolism by C. Elegans DBL-1/BMP SignalingR15GM112147 · NIGMS · QUEENS COLLEGE · PI SAVAGE-DUNN, CATHY · 2015 to 2019
$832k
NIGMS NIH HHS R15 GM112147NIGMS NIH HHS R15GM112147NIH HHS R24 OD010943NINDS NIH HHS R35 NS105092NINDS NIH HHS R35NS105092
6 · The paper itself

Abstract

Studies in genetically tractable organisms such as the nematode Caenorhabditis elegans have led to pioneering insights into conserved developmental regulatory mechanisms. For example, Smad signal transducers for the transforming growth factor beta (TGF-β) superfamily were first identified in C. elegans and in the fruit fly Drosophila. Recent studies of TGF-β signaling and the extracellular matrix (ECM) in C. elegans have forged unexpected links between signaling and the ECM, yielding novel insights into the reciprocal interactions that occur across tissues and spatial scales, and potentially providing new opportunities for the study of biomechanical regulation of gene expression.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsCollagenSignal TransductionTransforming Growth Factor betaCaenorhabditis elegans ProteinsCollagenTransforming Growth Factor betaBMPbody sizeC. eleganscollagenECMTGF-β

Identifiers

PMID34537996
PMCPMC8982858

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.