Evidence map›Paper›PMID 34539672›Full record

ArticleFrontiers in immunology2021

Glycoprotein Pathways Altered in Frontotemporal Dementia With Autoimmune Disease.

Fiona Bright, Jared S Katzeff, John R Hodges, Olivier Piguet, Jillian J Kril, Glenda M Halliday, Woojin Scott Kim

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Fiona BrightSchool of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.
Jared S KatzeffSchool of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.
John R HodgesSchool of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.
Olivier PiguetBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Jillian J KrilSchool of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.
Glenda M HallidaySchool of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.
Woojin Scott KimSchool of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.
University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Behavioral variant frontotemporal dementia (bvFTD) is a younger onset form of neurodegeneration initiated in the frontal and/or temporal lobes with a slow clinical onset but rapid progression. bvFTD is highly complex biologically with different pathological signatures and genetic variants that can exhibit a spectrum of overlapping clinical manifestations. Although the role of innate immunity has been extensively investigated in bvFTD, the involvement of adaptive immunity in bvFTD pathogenesis is poorly understood. We analyzed blood serum proteomics to identify proteins that are associated with autoimmune disease in bvFTD. Eleven proteins (increased: ATP5B, CALML5, COLEC11, FCGBP, PLEK, PLXND1; decreased: APOB, ATP8B1, FAM20C, LOXL3, TIMD4) were significantly altered in bvFTD with autoimmune disease compared to those without autoimmune disease. The majority of these proteins were enriched for glycoprotein-associated proteins and pathways, suggesting that the glycome is targeted in bvFTD with autoimmune disease.

Indexed as

Adaptive ImmunityAutoimmunityGlycomicsProteomeProteomicsAgedAged, 80 and overAutoimmune DiseasesBiomarkersFemaleFrontotemporal DementiaGlycoproteinsHumansMaleMiddle AgedPrevalenceBiomarkersGlycoproteinsProteomeautoimmune diseasebiomarkerfrontotemporal dementiaglycomeglycoproteinproteomicsserumthyroid

Identifiers

PMID34539672
PMCPMC8440893
OpenAlexW3198620130

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.