Evidence map›Paper›PMID 34541364›Full record

ArticleJournal of clinical and translational research2021

The genetics of cardiac failure: Role of a G protein-coupled receptor polymorphism in therapeutic response in an Indian population.

Sudha Ramalingam, Shanmugasundaram Radhakrishnan, Tamilarasu Kaliappan, Rajendiran Gopalan, Meenu Subrahmanian, Ramalingam Sankaran

Open access · diamondAbstract read
In one paragraph

Article in Journal of clinical and translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sudha RamalingamPSG Center for Molecular Medicine and Therapeutics, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
Shanmugasundaram RadhakrishnanDepartment of Cardiology, PSG Hospitals, Coimbatore, Tamil Nadu, India.
Tamilarasu KaliappanDepartment of Cardiology, PSG Hospitals, Coimbatore, Tamil Nadu, India.
Rajendiran GopalanDepartment of Cardiology, PSG Hospitals, Coimbatore, Tamil Nadu, India.
Meenu SubrahmanianPSG Center for Molecular Medicine and Therapeutics, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
Ramalingam SankaranPSG Center for Molecular Medicine and Therapeutics, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
KG Hospital · INPSG Institute of Medical Sciences & Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimThe incidence of heart failure (HF) is rising to epidemic proportions in developing countries like India. A lack of adequate Indian studies underscores the importance of pursuing research into HF in an Indian population. G protein-coupled receptor kinase 5 (

methodsHF patients (

resultsHF patients showed genotype frequencies of AT (15%) and TT (1%). AT/TT genotype carriers showed downregulated

conclusionsRELEVANCE FOR PATIENTS: This study presents a comprehensive clinicofunctional pharmacogenetic characterization of

Indexed as

genotypeGRK5heart failureIndiapolymorphismβ-blocker

Identifiers

PMID34541364
PMCPMC8445626
OpenAlexW3201519789

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.