Evidence map›Paper›PMID 34542769›Full record

ArticleBulletin of experimental biology and medicine2021

MRI-Based and Histologically Verified 3D Modeling of Spatial Distribution of Intra-Arterially Transplanted Cells in Rat Brain.

I L Gubskiy, D D Namestnikova, K K Sukhinich, V A Revkova, P A Melnikov, L V Gubsky, V P Chekhonin, K N Yarygin

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. 3D Modeling of Sculpture Nano-Ceramics under Sparse Image Sequence.International journal of analytical chemistry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

I L GubskiyFederal Center of Brain Research and Neurotechnologies, Federal Medical-Biological Agency of Russia, Ministry of Health of the Russian Federation, Moscow, Russia. gubskiy.ilya@gmail.com.
D D NamestnikovaFederal Center of Brain Research and Neurotechnologies, Federal Medical-Biological Agency of Russia, Ministry of Health of the Russian Federation, Moscow, Russia.
K K SukhinichN. K. Koltzov Institute of Developmental Biology, Moscow, Russia.
V A RevkovaFederal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Federal Medical-Biological Agency of Russia, Moscow, Russia.
P A MelnikovN. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
L V GubskyFederal Center of Brain Research and Neurotechnologies, Federal Medical-Biological Agency of Russia, Ministry of Health of the Russian Federation, Moscow, Russia.
V P ChekhoninN. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
K N YaryginN. V. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visualization of transplanted stem cells in the brain is an important issue in the study of the mechanisms of their therapeutic action. MRI allowing visualization of single transplanted cells previously labeled with superparamagnetic iron oxide particles is among the most informative methods of non-invasive intravital imaging. Verification of MRI data using pathomorphological examination at the microscopic level helps to avoid errors in data interpretation. However, making serial sections of the whole brain and searching for transplanted cells under the microscope is laborious and time-consuming. We have developed a method for 3D modeling of the distribution of transplanted cells in the brain allowing navigating through various brain structures and identifying the areas of accumulation of transplanted cells, which significantly increases the efficiency and reduces the time of histological examination.

Indexed as

AnimalsBrainCells, CulturedCell TrackingDisease Models, AnimalFemaleFerric CompoundsHumansImaging, Three-DimensionalInfarction, Middle Cerebral ArteryInfusions, Intra-ArterialIschemic StrokeMagnetic Resonance ImagingMagnetite NanoparticlesMaleMesenchymal Stem CellsFerric CompoundsMagnetite Nanoparticles3D modelingcell transplantationhistological examinationischemic strokeMRI

Identifiers

PMID34542769

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.