Evidence map›Paper›PMID 34544905›Full record

ArticleAging2021

Key genes affecting the progression of nasopharyngeal carcinoma identified by RNA-sequencing and bioinformatic analysis.

Yihong Wang, Manyi Li, Yan Guo, Haiping Huang, Xuelin Dong, Yangguang Sun, Jisheng Liu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Translational lung cancer research · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yihong WangDepartment of Otolaryngology, The First Affiliated Hospital of Soochow University, Soochow 215000, Jiangsu Province, China.
Manyi LiDepartment of Otolaryngology, The First Affiliated Hospital of Soochow University, Soochow 215000, Jiangsu Province, China.
Yan GuoDepartment of Otolaryngology, The First Affiliated Hospital of Soochow University, Soochow 215000, Jiangsu Province, China.
Haiping HuangDepartment of Otolaryngology, The First Affiliated Hospital of Soochow University, Soochow 215000, Jiangsu Province, China.
Xuelin DongDepartment of Otolaryngology, The First Affiliated Hospital of Soochow University, Soochow 215000, Jiangsu Province, China.
Yangguang SunDepartment of Otolaryngology, The First Affiliated Hospital of Soochow University, Soochow 215000, Jiangsu Province, China.
Jisheng LiuDepartment of Otolaryngology, The First Affiliated Hospital of Soochow University, Soochow 215000, Jiangsu Province, China.
First Affiliated Hospital of Soochow University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe present work was conducted to screen the potential biomarkers affecting nasopharyngeal carcinoma (NPC) progression through RNA-sequencing (RNA-seq), bioinformatic analysis and functional experiments. MATERIALS AND

methodsSix normal samples and five NPC clinical samples were collected for RNA-seq analysis. The expression levels in both groups were determined through student's

resultsA total of 2024 DEGs were identified, among which, 1449 were down-regulated and 575 were up-regulated. The PPI was constructed, and the hub genes including Insulin Like Growth Factor 1 (

conclusions

Indexed as

Biomarkers, TumorChemokine CXCL10Computational BiologyDisease ProgressionGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansInterleukin-13Matrix Metalloproteinase 1Matrix Metalloproteinase 3Nasopharyngeal CarcinomaNasopharyngeal NeoplasmsRNA-SeqBiomarkers, TumorChemokine CXCL10Interleukin-13Matrix Metalloproteinase 1Matrix Metalloproteinase 3differentially expressed genesnasopharyngeal carcinomaprogressionprotein encoding genesprotein-protein interaction network

Identifiers

PMID34544905
PMCPMC8507278
OpenAlexW3199304896

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.