Evidence map›Paper›PMID 34548089›Full record

Trial reportLipids in health and disease2021

Effects of an 8-week aerobic exercise program on plasma markers for cholesterol absorption and synthesis in older overweight and obese men.

S Mashnafi, J Plat, R P Mensink, P J Joris, J P D Kleinloog, S Baumgartner

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Lipids in health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03272061 (The Effects of Aerobic-based Exercise on Brain Vascular Function in Elderly Men), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03272061 nacompletednot on this map

The Effects of Aerobic-based Exercise on Brain Vascular Function in Elderly Men

TypeinterventionalSponsorMaastricht University Medical CenterRan2017 to 2018Enrolled19ConditionsPhysical Exercise, Cerebrovascular Function, Cerebral Blood Flow, Glucose MetabolismArmsAerobic-based exercise program
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

S MashnafiDepartment of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands.
J PlatDepartment of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands.
R P MensinkDepartment of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands.
P J JorisDepartment of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands.
J P D KleinloogDepartment of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands.
S BaumgartnerDepartment of Nutrition and Movement Sciences, NUTRIM school of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200, MD, Maastricht, the Netherlands. sabine.baumgartner@maastrichtuniversity.nl.
Maastricht University · NLAl Baha University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased physical activity is inversely related to the risk to develop cardiovascular disease (CVD). In a recent systematic review, it was reported that CVD patients had an increased cholesterol absorption and a decreased synthesis as compared with control participants. As increased physical activity levels reduce CVD risk, we hypothesized that exercise training will reduce cholesterol absorption and increase endogenous cholesterol synthesis in older overweight and obese men.

methodsA randomized, controlled, crossover trial was performed. Seventeen apparently healthy older overweight and obese men were randomized to start with an aerobic exercise or no-exercise control period for 8 weeks, separated by 12 weeks washout. Fasting serum total cholesterol (TC) and non-cholesterol sterol concentrations were measured at baseline, and after 4 and 8 weeks.

resultsThe aerobic exercise program did not affect serum TC concentrations. In addition, exercise did not affect TC-standardized serum concentrations of sitosterol and cholestanol that are markers for cholesterol absorption. However, a trend for reduced TC-standardized campesterol concentrations, which is another validated marker for cholesterol absorption, was observed as compared with control. Lathosterol concentrations, reflecting cholesterol synthesis, did not differ between both periods.

conclusionsAerobic exercise training for 8 weeks did not lower serum TC concentrations in older overweight and obese men, but a trend towards a decrease in the cholesterol absorption marker campesterol was found. The cholesterol synthesis marker lathosterol did not change.

trial registrationposted on www.clinicaltrials.gov as NCT03272061 on 7 September 2017.

Indexed as

ExerciseAgedBiomarkersBody Mass IndexCardiovascular DiseasesCholesterolCross-Over StudiesExercise TherapyHumansLife StyleMaleMiddle AgedObesityOverweightPhytosterolsSterolsBiomarkerscampesterolCholesterollathosterolPhytosterolsSterolsAerobic exerciseCholesterol absorptionCholesterol metabolismCholesterol precursorsCholesterol synthesisNon-cholesterol sterolsPlant sterols

Identifiers

PMID34548089
PMCPMC8454109
OpenAlexW3200889076

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.