Evidence map›Paper›PMID 34548526›Full record

Trial reportScientific reports2021

Vitamin D oral intermittent treatment (DO IT) study, a randomized clinical trial with individual loading regimen.

Jean-Pierre Rothen, Jonas Rutishauser, Philipp N Walter, Kurt E Hersberger, Isabelle Arnet

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jean-Pierre RothenPharmaceutical Care Research Group, Department of Pharmaceutical Sciences, University of Basel, Petersplatz 14, Postfach 2148, 4001, Basel, Switzerland. jp.rothen@unibas.ch.
Jonas RutishauserClinical Trial Unit, University Hospital of Basel, Kantonsspital Baden, Basel, Switzerland.
Philipp N WalterInstitute of Laboratory Medicine, Solothurner Spitäler, Switzerland.
Kurt E HersbergerPharmaceutical Care Research Group, Department of Pharmaceutical Sciences, University of Basel, Petersplatz 14, Postfach 2148, 4001, Basel, Switzerland.
Isabelle ArnetPharmaceutical Care Research Group, Department of Pharmaceutical Sciences, University of Basel, Petersplatz 14, Postfach 2148, 4001, Basel, Switzerland.
University of Basel · CHKantonsspital Baden · CHSolothurner Spitäler · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comparison of several regimens of oral vitamin D including an individually calculated loading regimen with the aim of achieving serum values > 75 nmol/l. Interventional, randomized, 3-arm study in vitamin D-deficient outpatients. Participants were allocated to supplementation of 24,000 IU vitamin D monthly over three months, using either a monthly drinking solution (Vi-De 3) or capsule (D

Indexed as

Administration, OralAdultAgedBiomarkersDietary SupplementsFemaleHumansMaleMiddle AgedPatient ComplianceVitamin DYoung AdultBiomarkersVitamin D

Identifiers

PMID34548526
PMCPMC8455639
OpenAlexW3201172112

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.