ArticleJournal of inflammation research2021
A Score of Low-Grade Inflammation for Predicting Stroke Recurrence in Patients with Ischemic Stroke.
Article in Journal of inflammation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Proteomic and Demographic Comparisons of Recurrent Ischemic Stroke Patients.Translational stroke research · 2025Article
- Low-grade Inflammation Score: a Risk Factor for Stroke Recurrence in Patients With Intracranial Atherosclerotic Stenosis.Molecular neurobiology · 2025Article
- Relationship between admission serum uric acid to lymphocyte ratio and the risk of ischemic stroke recurrence and death: a prospective study.Journal of global health · 2025Article
- Full-spectrum Cannabis sativa extract enhances gut-peripheral organ integrity after experimental ischemic stroke.Inflammopharmacology · 2025Article
- Impact of low-grade inflammation on neurological outcomes in patients with acute pontine infarction: a retrospective cohort study.Frontiers in immunology · 2025Article
- Plasma Soluble Angiotensin-Converting Enzyme 2 and Risk of Recurrent Stroke: A Nested Case-Control Analysis.Cerebrovascular diseases (Basel, Switzerland) · 2025Article
- Healthy eating patterns associated with reduced risk of inflammatory bowel disease by lowering low-grade inflammation: evidence from a large prospective cohort study.BMC medicine · 2024Article
- Clinical value of the low-grade inflammation score in aneurysmal subarachnoid hemorrhage.BMC neurology · 2023Article
- Applicability of the low-grade inflammation score in predicting 90-day functional outcomes after acute ischemic stroke.BMC neurology · 2023Observational
- The role of high-sensitivity C-reactive protein serum levels in the prognosis for patients with stroke: a meta-analysis.Frontiers in neurology · 2023Article
- Elevated white blood cell counts in ischemic stroke patients are associated with increased mortality and new vascular events.Frontiers in neurology · 2023Article
- Prediction of recurrence of ischemic stroke within 1 year of discharge based on machine learning MRI radiomics.Frontiers in neuroscience · 2023Article
- Baseline Objective Malnutritional Indices as Immune-Nutritional Predictors of Long-Term Recurrence in Patients with Acute Ischemic Stroke.Nutrients · 2022Article
- Prediction of Ischemic Stroke Recurrence Based on COX Proportional Risk Regression Model and Evaluation of the Effectiveness of Patient Intensive Care Interventions.Computational and mathematical methods in medicine · 2022Article
- The relationship between red blood cell distribution width at admission and post-stroke fatigue in the acute phase of acute ischemic stroke.Frontiers in neurology · 2022Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe impact of low-grade inflammation (LGI) on stroke recurrence has not been well studied yet. We aimed to evaluate the association between LGI and stroke recurrence in patients with ischemic stroke.
methodsPatients with first-ever ischemic stroke diagnosed within 72 hours of symptoms onset were consecutively recruited from the Nanjing Stroke Registry Program. C-reactive protein (CRP) level, white blood cell (WBC) count, platelet (PLT) count, and neutrophil-to-lymphocyte ratio (NLR) were conceived as low-grade inflammation biomarkers and combined into a standardized LGI score. The association of LGI score with the risk of stroke recurrence was analyzed with multivariate Cox regression models. Analyses accounting for the competing risk of stroke recurrence and death were also performed.
resultsOf the 1214 patients studied (median age, 61 years; male, 71.6%), 177 (14.6%) patients experienced a recurrent stroke with a median follow-up of 23.0 (interquartile ranges, 14.5-34.0) months. Patients with stroke recurrence had a higher LGI score (median, 3 versus -2;
conclusionThis study showed that an elevated LGI score was associated with a higher risk of stroke recurrence, independent of other vascular risk factors.
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