Evidence map›Paper›PMID 34550870›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature.

Paul B Dieffenbach, Christina Mallarino Haeger, Rakhshinda Rehman, Alexis M Corcoran, Anna Maria F Coronata, Shamsudheen K Vellarikkal, Izabela Chrobak, Aaron B Waxman, Sally H Vitali, Lynette M Sholl and 5 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. The emerging role of integrin signaling in pulmonary vascular disease.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. The Hippo Pathway in Breast Cancer: The Extracellular Matrix and Hypoxia.International journal of molecular sciences · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Pulmonary Hypertension: A Contemporary Review.American journal of respiratory and critical care medicine · 2023
    Review
  15. Article
  16. Review
  17. Article
  18. Mechanisms of pulmonary vascular dysfunction in pulmonary hypertension and implications for novel therapies.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  19. Frontiers in cellular and infection microbiology · 2022
    Article
  20. Matrix Metalloproteinase-8 in Pulmonary Hypertension: The Sheep in the Wolf's Skin?American journal of respiratory and critical care medicine · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Paul B DieffenbachDivision of Pulmonary and Critical Care Medicine and.
Christina Mallarino HaegerDivision of Pulmonary and Critical Care Medicine and.
Rakhshinda RehmanDivision of Pulmonary and Critical Care Medicine and.
Alexis M CorcoranDivision of Pulmonary and Critical Care Medicine and.
Anna Maria F CoronataDivision of Pulmonary and Critical Care Medicine and.
Shamsudheen K VellarikkalBroad Institute of MIT and Harvard University, Cambridge, Massachusetts.
Izabela ChrobakLovelace Respiratory Research Institute, Albuquerque, New Mexico.
Aaron B WaxmanDivision of Pulmonary and Critical Care Medicine and.ORCID 0000-0001-7797-0361
Sally H VitaliDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts; and.
Lynette M ShollDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
Robert F PaderaDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
David LagaresDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0002-7317-8796
Francesca PolverinoDivision of Pulmonary and Critical Care Medicine and.ORCID 0000-0001-9686-5698
Caroline A OwenDivision of Pulmonary and Critical Care Medicine and.
Laura E FredenburghDivision of Pulmonary and Critical Care Medicine and.ORCID 0000-0002-7447-6453
Pulmonary and Critical Care Associates · USBrigham and Women's Hospital · USBoston Children's Hospital · USBroad Institute · USLovelace Respiratory Research Institute · USMassachusetts General Hospital · US

Funding

RESPIRATORY RESEARCHT32HL007633 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI George R Washko · 1985 to 2026
$14.9M
Pulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1M
Mechanotransduction and YAP/TAZ Signaling in Pulmonary Arterial HypertensionR01HL137366 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PERRELLA, MARK A, TSCHUMPERLIN, DANIEL J. · 2018 to 2021
$2.7M
Targeting the ADAM10-sEphrin-B2 pathway in pulmonary fibrosisR01HL147059 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEDOFF, BENJAMIN DAVID · 2019 to 2023
$2.1M
Mechanobiology of Vascular Remodeling in Pulmonary Arterial HypertensionR01HL114839 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FREDENBURGH, LAURA ELIZABETH · 2012 to 2016
$2.1M
YAP/TAZ-mediated Mechanotransduction in Pulmonary Hypertension PathogenesisK08HL143197 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIEFFENBACH, PAUL BRIAN · 2018 to 2021
$679k
Arterial Stiffness in the Pathogenesis of Human Pulmonary Arterial HypertensionR03HL115106 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FREDENBURGH, LAURA ELIZABETH · 2012 to 2013
$174k
Pulmonary Vascular Cellular Response to Pathologic Matrix Stiffness in Pulmonary Arterial HypertensionF32HL131228 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIEFFENBACH, PAUL BRIAN · 2016 to 2017
$143k
American Heart Association-American Stroke Association 17GRNT33660449NHLBI NIH HHS F32 HL131228NHLBI NIH HHS K08 HL143197NHLBI NIH HHS R01 HL114839NHLBI NIH HHS R01 HL137366NHLBI NIH HHS R01 HL147059NHLBI NIH HHS R03 HL115106NHLBI NIH HHS R24 HL123767NHLBI NIH HHS T32 HL007633
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAnimalsBiomarkersCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMatrix Metalloproteinase 8MiceMice, Inbred C57BLMice, KnockoutMiddle AgedPulmonary Arterial HypertensionPulmonary ArteryBiomarkersMatrix Metalloproteinase 8cellular mechanotransductionintegrin-β3pulmonary arterial hypertensionpulmonary artery smooth muscle cellsYAP/TAZ

Identifiers

PMID34550870
PMCPMC8865706
OpenAlexW3200765796

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.