Evidence mapPaperPMID 34551157Full record

ArticleScandinavian journal of medicine & science in sports2021

Angiotensin-Converting Enzyme 2 (SARS-CoV-2 receptor) expression in human skeletal muscle.

Mario Perez-Valera, Miriam Martinez-Canton, Angel Gallego-Selles, Victor Galván-Alvarez, Miriam Gelabert-Rebato, David Morales-Alamo, Alfredo Santana, Saul Martin-Rodriguez, Jesus Gustavo Ponce-Gonzalez, Steen Larsen and 13 more

Open access · hybridAbstract read
In one paragraph

Article in Scandinavian journal of medicine & science in sports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Rhabdomyolysis After COVID-19.The Medical journal of Australia · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Advance in the mechanism and clinical research of myalgia in long COVID.American journal of clinical and experimental immunology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. The effects of biological sex and cardiovascular disease on COVID-19 mortality.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  13. Review
  14. Angiotensin-Converting Enzyme 2 (SARS-CoV-2 receptor) expression in human skeletal muscle.Scandinavian journal of medicine & science in sports · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 6 institutions in 6 countries.

Mario Perez-ValeraDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0002-8332-729X
Miriam Martinez-CantonDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0002-2925-3429
Angel Gallego-SellesDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0002-8068-9586
Victor Galván-AlvarezDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0002-1272-3471
Miriam Gelabert-RebatoDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0002-8963-5568
David Morales-AlamoDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0001-8463-397X
Alfredo SantanaResearch Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Saul Martin-RodriguezDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0003-2423-5309
Jesus Gustavo Ponce-GonzalezDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0002-5982-7761
Steen LarsenCenter of Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-5170-4337
Jose Losa-ReynaDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0001-9545-5654
Ismael Perez-SuarezDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0002-7969-0061
Cecilia DoradoDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0001-6616-6810
David CurtelinResearch Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0001-6462-382X
Juan Jose Gonzalez-HenriquezDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0002-0622-5580
Robert BoushelSchool of Kinesiology, Faculty of Education, The University of British Columbia, Vancouver, British Columbia, Canada.
Jostein HallenDepartment of Physical Performance, The Norwegian School of Sport Sciences, Oslo, Norway.ORCID https://orcid.org/0000-0002-6646-0734
Pedro de Pablos VelascoResearch Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0002-9190-2581
Jorge Freixinet-GilartDepartment of Thoracic Surgery, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
Hans-Christer HolmbergDepartment of Physiology and Pharmacology, Biomedicum C5, Karolinska Institute, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-3814-6246
Jorn W HelgeCenter of Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-9724-5423
Marcos Martin-RinconDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0002-3685-2331
Jose A L CalbetDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.ORCID https://orcid.org/0000-0002-9215-6234
Universidad de Las Palmas de Gran Canaria · ESUniversity of Copenhagen · DKHospital Universitario de Gran Canaria Doctor Negrín · ESLuleå University of Technology · SENorwegian School of Sport Sciences · NOUniversity of British Columbia · CA

Funding

Agencia Canaria de Investigación, Innovación y Sociedad de la InformaciónInstituto de Salud Carlos IIIMinisterio de Economía, Industria y Competitividad, Gobierno de EspañaUniversidad de Las Palmas de Gran Canaria
6 · The paper itself

Abstract

The study aimed to determine the levels of skeletal muscle angiotensin-converting enzyme 2 (ACE2, the SARS-CoV-2 receptor) protein expression in men and women and assess whether ACE2 expression in skeletal muscle is associated with cardiorespiratory fitness and adiposity. The level of ACE2 in vastus lateralis muscle biopsies collected in previous studies from 170 men (age: 19-65 years, weight: 56-137 kg, BMI: 23-44) and 69 women (age: 18-55 years, weight: 41-126 kg, BMI: 22-39) was analyzed in duplicate by western blot. VO

Indexed as

AdiposityCardiorespiratory FitnessCOVID-19ExerciseAdolescentAdultAngiotensin-Converting Enzyme 2BiopsyCross-Sectional StudiesEnergy MetabolismFemaleHumansMaleMiddle AgedMuscle, SkeletalSARS-CoV-2Angiotensin-Converting Enzyme 2ACE2biopsiescardiorespiratory fitnessCOVID-19exerciseobesitysex differencesVO2max

Identifiers

PMID34551157
PMCPMC8662278
OpenAlexW3199881521

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.