ArticleCell reports2021
CCR2 deficiency alters activation of microglia subsets in traumatic brain injury.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Pooled it
- Dynamic metabolic programming of monocyte-derived cells defines immunity in CNS disease.Brain : a journal of neurology · 2026Review
- Traumatic Brain Injury and the Road to Alzheimer's Disease.Biomedicines · 2026Review
- FcγR- and CD9-dependent synapse-engulfing microglia in the thalamus drive cognitive impairment following cortical brain damage in mice.Nature communications · 2026Article
- Single-cell RNA sequencing in stroke and traumatic brain injury: Current achievements, challenges and future perspectives on transcriptomic profiling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- USP4 modulates ZBP1 ubiquitination to regulate microglial PANoptosis and functional outcomes following traumatic brain injury.Cell death and differentiation · 2026Article
- Hematopoietic cell kinase regulates microglial/macrophage activation to drive neuroinflammation after traumatic brain injury.Cell communication and signaling : CCS · 2026Article
- The Dynamics of Neuroinflammation in Traumatic Brain Injury: Molecular Markers Useful for Establishing the Post-Traumatic Interval in Forensic Practice.International journal of molecular sciences · 2026Review
- Article
- CSF1R and IL1R1 inhibitors synergistically attenuate the early pathogenesis of traumatic brain injury in mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Microbial production of short-chain fatty acids attenuates long-term neurologic impairment after traumatic brain injury.Journal of neuroinflammation · 2025Article
- The border-associated macrophage marker MRC1 contributes to an early neuroprotective inflammatory response to traumatic brain injury in mice.Acta neuropathologica communications · 2025Article
- Fate mapping of peripherally-derived macrophages after traumatic brain injury in mice reveals a long-lasting population with a distinct transcriptomic signature.Nature communications · 2025Article
- Single-cell transcriptomics of neuroinflammation and cerebrovascular endothelial cells in the aged rat hippocampus.iScience · 2025Article
- Unlocking therapeutic potential in traumatic brain injury: exploring microenvironmental targets, signaling pathways and translational hurdles.Inflammopharmacology · 2025Review
- Single cell RNA sequencing after moderate traumatic brain injury: effects of therapeutic hypothermia.Journal of neuroinflammation · 2025Article
- A central role for CCR2 in monocyte recruitment and blood-brain barrier disruption during Usutu virus encephalitis.Journal of neuroinflammation · 2025Article
- High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis.Cell death discovery · 2025Article
- Long-lasting changes in circulating dendritic cell and monocyte subsets, and altered expression of EMR2, CD97 and EMR3 on these cells in the posttraumatic course.Clinical & translational immunology · 2025Article
- Blood Levels of Dendritic Cell Populations in Patients with Moderate to Severe Traumatic Brain Injury.Neurotrauma reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 8 institutions in 1 country.
Kerri SomebangDepartment of Medicine, Division of Rheumatology, University of California, San Francisco (UCSF), San Francisco, CA, USA; San Francisco VA Health Care System, San Francisco, CA, USA.
Joshua RudolphSchool of Medicine, Lung Biology Center, Division of Pulmonology, UCSF, San Francisco, CA, USA.
Isabella ImhofDepartment of Medicine, Division of Rheumatology, University of California, San Francisco (UCSF), San Francisco, CA, USA; San Francisco VA Health Care System, San Francisco, CA, USA.
Luyi LiDepartment of Medicine, Division of Rheumatology, University of California, San Francisco (UCSF), San Francisco, CA, USA; San Francisco VA Health Care System, San Francisco, CA, USA.
Erene C NiemiDepartment of Medicine, Division of Rheumatology, University of California, San Francisco (UCSF), San Francisco, CA, USA; San Francisco VA Health Care System, San Francisco, CA, USA.
Judy ShigenagaSan Francisco VA Health Care System, San Francisco, CA, USA; Department of Medicine, Division of Endocrinology and Metabolism, UCSF, San Francisco, CA, USA.
Huy TranSan Francisco VA Health Care System, San Francisco, CA, USA.
T Michael GillGladstone Institutes, San Francisco, CA, USA.
Iris LoGladstone Institutes, San Francisco, CA, USA.
Brian A ZabelPalo Alto Veterans Institute for Research, Palo Alto, CA, USA; Palo Alto VA Health Care System, Palo Alto, CA, USA.
Gabriela SchmajukDepartment of Medicine, Division of Rheumatology, University of California, San Francisco (UCSF), San Francisco, CA, USA; San Francisco VA Health Care System, San Francisco, CA, USA.
Brian T WipkeBiogen, Cambridge, MA, USA.
Stefka GyonevaBiogen, Cambridge, MA, USA.
Luke JandreskiBiogen, Cambridge, MA, USA.
Michael CraftBiogen, Cambridge, MA, USA.
Gina BenedettoBiogen, Cambridge, MA, USA.
Edward D PloweyBiogen, Cambridge, MA, USA.
Israel CharoChemoCentryx, Mountain View, CA, USA.
James CampbellChemoCentryx, Mountain View, CA, USA.
Chun Jimmie YeDepartment of Medicine, Division of Rheumatology, University of California, San Francisco (UCSF), San Francisco, CA, USA; Institute for Human Genetics, Department of Epidemiology and Biostatistics, Institute of Computational Health Sciences, University of California, San Francisco, San Francisco, CA, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA.
S Scott PanterSan Francisco VA Health Care System, San Francisco, CA, USA; Department of Neurological Surgery, UCSF, San Francisco, CA, USA.
Mary C NakamuraDepartment of Medicine, Division of Rheumatology, University of California, San Francisco (UCSF), San Francisco, CA, USA; San Francisco VA Health Care System, San Francisco, CA, USA.
Walter EckalbarSchool of Medicine, Lung Biology Center, Division of Pulmonology, UCSF, San Francisco, CA, USA.
Christine L HsiehDepartment of Medicine, Division of Rheumatology, University of California, San Francisco (UCSF), San Francisco, CA, USA; San Francisco VA Health Care System, San Francisco, CA, USA. Electronic address: christine.hsieh@ucsf.edu.
Biogen (United States) · USUniversity of California, San Francisco · USSan Francisco VA Health Care System · USChemoCentryx (United States) · USGladstone Institutes · USNeurological Surgery · USPalo Alto Veterans Institute for Research · USParker Institute for Cancer Immunotherapy · US
Funding
RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2MGenetic regulation and immunological function of ERAP2 haplotypesR01AI136972 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YE, CHUN JIMMIE · 2018 to 2022
$3.5MInnate immune regulation of stem cells in bone formationR01AR066735 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSIAO, EDWARD C · 2015 to 2019
$1.8MFine mapping rheumatic disease variants using functional genomic sequencingR01AR071522 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YE, CHUN JIMMIE · 2017 to 2020
$1.5MGenetic variation impacting the airway smooth muscle in children with asthmaR00HL135403 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ECKALBAR, WALTER · 2020 to 2022
$747kFine mapping rheumatic disease variants using functional genomic sequencingU01HG012192 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YE, CHUN JIMMIE · 2021 to 2021
$526kNew Approaches to Combat CNS Inflammation: Targeting a Metabolic Enzyme in Demyelinating DiseaseI01BX004115 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI BRIAN A. ZABEL · 2019 to 2026
–Immune Modulation and Cardiac RemodelingI01BX002994 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI KARLINER, JOEL SAMUEL, NAKAMURA, MARY C · 2017 to 2020
–Targeting CCR2 (CC Chemokine Receptor 2) to treat TBII01BX002690 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI CHRISTINE LINDA HSIEH · 2016 to 2026
–BLRD VA I01 BX002690BLRD VA I01 BX002994BLRD VA I01 BX004115NHGRI NIH HHS U01 HG012192NHLBI NIH HHS R00 HL135403NIAID NIH HHS R01 AI136972NIAMS NIH HHS P30 AR070155NIAMS NIH HHS R01 AR066735NIAMS NIH HHS R01 AR071522
Abstract
In traumatic brain injury (TBI), a diversity of brain resident and peripherally derived myeloid cells have the potential to worsen damage and/or to assist in healing. We define the heterogeneity of microglia and macrophage phenotypes during TBI in wild-type (WT) mice and Ccr2
Indexed as
AnimalsAntigens, LyBrainBrain Injuries, TraumaticChemokine CXCL10Disease Models, AnimalDown-RegulationHumansInterferon Regulatory Factor-7Interferon Type IMacrophagesMaleMaze LearningMiceMice, Inbred C57BLMice, KnockoutAntigens, LyChemokine CXCL10Cxcl10 protein, mouseInterferon Regulatory Factor-7Interferon Type IIrf7 protein, mouseLy-6C antigen, mouseReceptors, CCR2CCR2dendritic cellsinnate immunitymacrophagesmicrogliamonocytesneuroinflammationsingle-cell RNA sequencingtraumatic brain injurytype I IFN
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.