Evidence map›Paper›PMID 34553185›Full record

ArticleAmerican journal of preventive cardiology2021

Abdominal subcutaneous adipose tissue negatively associates with subclinical coronary artery disease in men with psoriasis.

Meron Teklu, Wunan Zhou, Promita Kapoor, Nidhi Patel, Martin P Playford, Alexander V Sorokin, Amit K Dey, Heather L Teague, Grigory A Manyak, Justin A Rodante and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of preventive cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Meron TekluNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Wunan ZhouNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Promita KapoorNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Nidhi PatelNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Martin P PlayfordNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Alexander V SorokinNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Amit K DeyNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Heather L TeagueNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Grigory A ManyakNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Justin A RodanteNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Andrew KeelNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Marcus Y ChenNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
David A BluemkeDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Amit V KheraCenter for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Nehal N MehtaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health · USNational Heart Lung and Blood Institute · USMassachusetts General Hospital · USUniversity of Wisconsin–Madison · US

Funding

Polygenic prediction of common, complex diseasesK08HG010155 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI KHERA, AMIT VIKRAM · 2018 to 2021
$1.1M
NHGRI NIH HHS K08 HG010155
6 · The paper itself

Abstract

objectiveUnderstand the relationship between abdominal subcutaneous adipose tissue (ASAT) and coronary atherosclerosis defined as noncalcified and lipid-rich necrotic core burden in psoriasis.

methodsWe performed a cross-sectional study of 232 participants (92 women) with psoriasis and without known cardiovascular disease. Participants underwent coronary computed tomography angiography to characterize coronary atherosclerosis burden and low dose abdominal computed tomography to quantify subcutaneous and visceral adipose tissue. Fat depot volumes were first adjusted for each participant's BMI (ASAT

resultsIn women, there was a positive correlation between ASAT

conclusionsFor a given BMI, ASAT negatively associated with coronary atherosclerosis burden in male participants with psoriasis. The observed sex-specific effects warrant further study of ASAT in states of chronic inflammation.

Indexed as

Abdominal obesityCardiovascular diseaseInflammation

Identifiers

PMID34553185
PMCPMC8441148
OpenAlexW3193972400

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.